The invention relates to a sensing system comprising at least one light emitting source, a sensing element comprising a sensing area, and an optical means for directing light being emitted by the at least one light emitting source onto the sensing area of the sensing element and for directing light being transmitted or reflected from the sensing area of the sensing element to an integrated interrogator; the interrogator having at least one detector configured for detecting part of the spectrum of the light directed from the sensing area of the sensing element.

A photonic crystal for detection of an analyte includes: a first layer including a first material with a first refractive index; a second layer over the first layer and including a second material with a second refractive index that is higher than the first refractive index; where the second layer includes a hole, the hole including: a first diameter from an outer surface of the second layer to a first hole depth; a second diameter from the first hole depth to a second hole depth; where the first diameter is larger than the second diameter; and a member of a binding pair with the analyte linked to a surface of the hole.

A guided mode resonance (GMR) sensor assembly and system are provided. The GMR sensor includes a waveguide structure configured for operation at or near one or more leaky modes, a receiver for input light from a source of light onto the waveguide structure to cause one or more leaky TE and TM resonant modes and a detector for changes in one or more of the phase, waveshape and/or magnitude of each of a TE resonance and a TM resonance to permit distinguishing between first and second physical states of said waveguide structure or its immediate environment.

A resin impregnation detection device configured to detect resin impregnation in a resin impregnation process for a coil insulation layer. The resin impregnation detection device can be inserted in a narrow portion, is capable of detecting impregnation with a liquid resin, and does not leave metal foreign materials other than an optical fiber in a product even after the resin impregnation. The resin impregnation detection device includes an optical fiber including an FBG sensor, and a coating resin, which coats the FBG sensor. The coating resin includes a resin to be softened by contact with a detection target resin. The FBG sensor is applied with a compressive strain caused by cure shrinkage of the coating resin or heat shrinkage thereof from a curing temperature to a normal temperature.

A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

A linear actuation screw having a first end portion, a second end portion on an opposite side as the first end portion, and a sloping intermediate portion between the first end portion and second end portion. The first end portion has a threaded outer wall having a generally constant first diameter over at least a portion of its length and is configured to advance a nut or a sliding member along at least a portion of the first end portion. The second end portion has a threaded outer wall having a generally constant second diameter that is different from the first diameter and is configured to receive a motor fastening nut around it in order to secure the linear actuation screw to a motor. The sloping intermediate portion includes an outer wall that is generally smooth and continuous over at least a majority of the area of the outer wall.

A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.

An analysis plate including: a substrate; and a molecule immobilized on a surface of the substrate, the molecule specifically recognizing a measurement target substance, wherein the substrate includes a selective reflection layer in at least part of the layer thereof. Preferably, the surface of the substrate has a concavo-convex structure capable of exhibiting a structural color. Preferably, a band of light reflection caused by a selective reflectivity of the selective reflection layer falls within a band of light reflection caused by the concavo-convex structure. Also provided are an analysis method using the same and a production method thereof.

Under one aspect, a device is provided for use in luminescent imaging. The device can include a photonic superlattice including a first material, the first material having a first refractive index. The first material can include first and second major surfaces and first and second pluralities of features defined through at least one of the first and second major surfaces, the features of the first plurality differing in at least one characteristic from the features of the second plurality. The photonic superlattice can support propagation of a first wavelength and a second wavelength approximately at a first angle out of the photonic superlattice, the first and second wavelengths being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice.

A diffractive biosensor for selective detection of biomolecules includes a substrate and a flat waveguide disposed on the substrate. The waveguide has an optical grating configured to couple incident light into the waveguide such that the light is guided through the waveguide to a detection region located behind an edge of the waveguide. The in-coupling efficiency and intensity of the light arriving in the detection region are dependent on a surface coverage of the optical grating with the biomolecules to be detected. The optical grating has receptors for the biomolecules periodically arranged on the waveguide. The light incident on the optical grating is collimated.