A method and device detect defects in the closure of encapsulated vials. The method includes scanning a profile of the capsule and of the vial using a profilometer, thus obtaining a point cloud. From the point cloud obtained, calculating at least one of the following parameters: diameter or radius of the closure circumference of the capsule; angle of intersection between the lower skirt and the side of the capsule; length of the lower skirt; and/or a distance from the end of the lower skirt to the neck of the vial. The method determines whether any of the parameters calculated in the previous step exceeds a predetermined value. The device detecting defects in the closure of encapsulated vials includes a profilometer configured to scan a profile of the capsule and of the vial and a control device configured to execute the method.

Nephelometric measuring devices are described. The nephelometric measuring devices can be configured such that an amount of scattered light having different pathlengths impingent upon one or more scattered-light detectors from a beam propagating through a suspension can result in substantially equivalent sensitivity and in correlation between the scattered-light detectors' response and a turbidity value of the suspension. The response of the scattered-light detector(s) receiving scattered light at a nephelometric angle of 85-110? from a beam of light propagating through the suspension can be in accordance to an equation selected from a group of non-linear equations where:

x/y=aoxn+ ++a2x.sup.2+aix+ao; where n is an integer greater than 0; x is equal to the turbidity value of the suspension; y is equal to the response of the scattered-light detector; and an are calibration coefficients. The maximum response of the scattered-light detector occurs at a turbidity value dependent upon the effective scattered-light pathlength.

An inspection system capable of identifying particles within a liquid container such as a vial or syringe. The inspection system captures images of a container after it has stopped spinning while it is moving in a linear path through the field of view of an imager. A plurality of images are captured of the container at different positions within the field of view. The images are registered to each other and combined in order to identify particles that have moved between images, which are considered particles.

A plurality of reference lines are set with regard to a blob (78) in a target image. The blob (78) is structured from an outside section serving as a low-luminance section, and an inside section (84) serving as a high-luminance section. An air bubble determination condition includes an edge pair condition. The edge pair condition is determined to be satisfied if two edge pairs EP1, EP2 are detected on any one of the reference lines (100). The air bubble determination condition may include an edge gap condition.

The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.

A foreign matter inspection system that is less likely to misidentify a crack as a foreign matter during an image inspection in which a vibration is applied to a powder contained in a bag-like container. The foreign matter inspection system includes a vibration device configured to apply a vibration to a container, a photography device configured to optically photograph the inside of the container through a transparent area, and a determination device configured to determine whether a foreign matter is present inside the container based on an image of the container photographed by the photography device. The vibration device alternately applies weak vibrations W and strong vibrations S to the container. The determination device determines whether the foreign matter is present inside the container based on the image of the container photographed by the photography device when the vibration device applies the weak vibrations W.

A method for measuring a concentration of a gas in a container having a wall with at least one deformable portion, the gas absorbing electromagnetic radiation at least in a specific spectral range, wherein the method includes the steps of biasing deformable portion and a further portion of wall opposite deformable portion between opposite positioning surfaces, thereby forming a biased volume of the container between the opposite positioning surfaces, during a measuring time, transmitting electromagnetic radiation into biased volume and receiving transmitted or reflected radiation of transmitted radiation from biased volume along respective radiation paths, relatively moving, during measuring time, at least one of deformable portion and of further portion and at least one of radiation paths, and determining concentration of said gas from the radiation received.

The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.

According to an aspect of the invention, a specimen information detection apparatus includes, an image capture device configured to capture an image of a specimen container that contains a specimen, an illumination device configured to irradiate the specimen container with light sideways with respect to an image capturing direction when the image is captured, and an information processing portion configured to detect a state in the specimen container through image processing based on image information of the specimen container acquired by capturing the image of the specimen container.

Methods and apparatus of inspection tools for inspecting impurities in vials are provided herein. In some embodiments, an inspection tool for inspecting impurities in vials includes: a table for inspecting a plurality of vials; one or more carts configured to move about the table to place the one or more carts in an inspection position, wherein each of the one or more carts includes a vial holder configured to hold a plurality of vials, and wherein each vial holder is configured to spin the plurality of vials on their own respective axes; and a camera configured to take images of the plurality of vials when the plurality of vials are disposed in the inspection position.