Described herein are systems and methods used for carrying out a two-dimensional liquid chromatography process using size exclusion chromatography as a first dimension.

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

An object of the present invention is to provide a highly versatile analyzing device that widens a range of analysable samples. There is provided an analyzing device 10 including: a splitting part 110 for causing fluid containing a sample component to flow separately in a first flow passage and a second flow passage; an analyzing column 109 provided on the first flow passage for separating the sample component from the fluid; a first back pressure regulating valve 111 corresponding to a first pressure controlling unit for controlling a pressure in the first flow passage; and a second back pressure regulating valve 112 corresponding to a second pressure controlling unit for controlling a pressure in the second flow passage, wherein flow rate of the fluid in the first flow passage and flow rate of the fluid in the second flow passage are controlled based on a ratio of the pressure in the first flow passage to the pressure in the second flow passage.

An object of the present invention is to provide a highly versatile analyzing device that widens a range of analysable samples. There is provided an analyzing device 10 including: a splitting part 110 for causing fluid containing a sample component to flow separately in a first flow passage and a second flow passage; an analyzing column 109 provided on the first flow passage for separating the sample component from the fluid; a first back pressure regulating valve 111 corresponding to a first pressure controlling unit for controlling a pressure in the first flow passage; and a second back pressure regulating valve 112 corresponding to a second pressure controlling unit for controlling a pressure in the second flow passage, wherein flow rate of the fluid in the first flow passage and flow rate of the fluid in the second flow passage are controlled based on a ratio of the pressure in the first flow passage to the pressure in the second flow passage.

A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

Described herein is a method and a system for automated simultaneous control of at least two process characteristics of a continuous production process with at least one fluid stream, at least two unit operations, at least one process control system and at least one conditioning volume.

A method for producing a pneumatic module, a gas analysis device comprising at least one such pneumatic module, a computer program product via which the operating characteristics of a corresponding pneumatic module can be simulated, wherein the pneumatic module serves to adjust a fluid flow and is deployable in the gas analysis device and includes a support sleeve and a flow module that is contained in the support sleeve, where the flow module is connected at a first end thereof to the support sleeve in order to achieve greater measuring accuracy of the gas analysis device.

A main controller 201 of a main substrate 20 performs serial communications with a sub controller 214 of each flowrate control substrate 21. The flowrate of the carrier gas is controlled with the flowrate control circuit 213 under the control performed by each sub controller 214. Thus, the main controller 201 only needs to execute the processing of performing the serial communications with each sub controller 214. As a result, the processing executed by the main controller 201 can be reduced, and the processing executed by the main controller 201 is less likely to overwhelm its processing capability even when the number of flowrate control substrates 21 is increased. In addition, a signal line 40 between the main controller 201 and each sub controller 214 can be made long. Thus, the distance between the main substrate 20 and each of the flowrate control substrates 21 can be made long.

A high-duty-cycle liquid chromatography system that includes two or more columns that are configured to alternatingly be in a productive phase or a regeneration phase, wherein simultaneously one of the columns is in a productive phase and the other columns are in the regeneration phase. Additionally, the system includes a mobile phase gradient delivery pump, an isocratic pump, two or more gradient storage chambers, and two or more valves that are each independently coupled to a column and a gradient storage chamber. The column in the productive phase has a solution containing a sample which is pushed through the column, collected at a detector, and analyzed. The column in the regeneration phase is being prepared for the next productive phase.