Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

A first solution is supplied from a first pump. A second solution is supplied from a second pump. A flow path from the first pump and the second pump to a column is switched between a first flow path and a second flow path. In the first flow path, a first mixer is located upstream of an injection part for a sample, and the second mixer is located downstream of the injection part. In the second flow path, the first mixer and the second mixer are located upstream of the injection part. The first flow path is formed in a first mode in which the sample is diluted before introduction into the column. The second flow path is formed in a second mode in which the sample is not diluted before introduction into the column.

The invention relates to a system and micro monitor apparatus, a space-, time-, and cost-efficient device to concentrate, identify, and quantify organic compounds in gas environments. The invention further relates to a method centered on gas chromatography for identifying and quantifying organic compounds in gas environments, using air as the carrier gas, without the need for a compressed pre-bottled purified carrier gas.

The present invention relates to a method of operating a fluidic system, wherein the fluidic system comprises a fluidic resistive element, wherein the method comprises a defined volume flow step, wherein in the defined volume flow step, a defined volume of a fluid is forced to flow out of the fluidic resistive element, wherein the defined volume is the fluid flowing out of the fluidic resistive element in a first time interval defined by a time t.sub.start and a time t.sub.end, wherein the defined volume flow step comprises: at the time t.sub.start, switching the system from a first operating state to a second operating state, to bring a pressure in the fluidic resistive element from a first pressure value to a second pressure value, the second pressure value exceeding the first pressure value, and at a time t.sub.reduce, which is after the time t.sub.start and not later than the time t.sub.end, switching the system to a third operating state to bring the pressure in the fluidic resistive element to a third pressure value, the third pressure value being below the second pressure value. The present invention also relates to a corresponding system and a corresponding computer program product.

A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.

An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

A preparative chromatograph includes a separation column, and a detector provided downstream of the separation column. Furthermore, the preparative chromatograph includes a fractionator including a gas-liquid separator configured to separate a fluid containing components of a sample into a gas and a liquid, the fractionator being provided downstream of the detector. The preparative chromatograph is configured to supply carbon dioxide to a flow path between the separation column and the fractionator.

A storage container includes a casing and a bi-parting door. The casing has an opening and stores a device to be used in a fluid chromatograph. A door of the bi-parting door includes a frame member and a cover member. The frame member includes an upper frame and a lower frame. The upper frame and the lower frame are provided at the casing to be turnable around a turning axis and be spaced apart from each other on the turning axis. The cover member is configured to be attachable to and detachable from the frame member and partially cover the opening when the door is closed. A space is formed between the upper frame and the lower frame.

Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector. A first and second fluid pump manager control the flow of a first and second fluid to one or more heating/cooling devices, and a mixer receives and mixes the first and second fluids. An optical detector flow cell receives the fluid mixture from the mixer, and a pressure regulator controls the pressure at the optical detector flow cell. Thus, the composition, temperature, and pressure of a fluid mixture entering an optical detector flow cell can be controlled in real time.