The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

A sample injection device includes: a sample container; a sample loop; a syringe, a liquid transfer channel; a first channel switching valve that switches the sample loop to be detachable to the liquid transfer channel; and a second channel switching valve that switches the channel of the syringe together with the first channel switching valve.

An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper 109 and injected into the verification flow paths 122 and 123, and holding time when a baseline of the detector 125 changes is stored in the control unit 130. The air in the verification flow paths 122 and 123 of the stream 101 and the stream 102 is measured, and holding time of the stream 101 and holding time of the stream 102 are compared to determine whether or not there is a difference of 1 second or more in the holding time. When the difference in holding time is 1 second or more, correction is performed. Holding time information of the same verification flow paths 122 and 123 in the stream 101 and the stream 102 are compared with holding time information stored in the control unit 130 and correction is performed when the difference in holding time is 1 second or more.

A liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream, the fluidic stream comprising a sample-injection valve, a trap-bypass-selection valve, a column-bypass valve, a load-elute valve and a trap-selection valve. Also, a liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream. The fluidic stream comprises a first substream and a second substream. The first substream comprises a first sample-injection valve, a load-elute valve and a trap-selection valve. The second substream comprises a second sample-injection valve and a column-bypass valve. The fluidic stream further comprises a trap-LC substream transfer valve and a substream-selection valve. The LC systems provide a broad choice of chromatographic options and modes and enable to flexibly and rapidly switch between them.

The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.

An autosampler includes a retention path for injecting a sample into a mobile phase that flows through an analysis path to a column, the retention path including a needle at a downstream end and holding the sample, an injection path including a port at an upstream end for injecting into the analysis path, the sample injected from the needle into the port, a low-pressure path having an upstream end connected to a pump, and a valve that can switch between a first state in which an upstream analysis path and a downstream analysis path are connected and a downstream end of the low-pressure path and an upstream end of the retention path are connected and a second state in which the upstream analysis path and the upstream end of the retention path are connected and the downstream end of the injection path and the downstream analysis path are connected.

In a gas chromatograph configured so that a gas type of carrier gas can be changed, automatic recognition of the gas type of the carrier gas is enabled. The gas chromatograph includes a sample gas generation part (2) configured to generate a sample gas using a sample injected thereinto, a separation column (6) fluidly connected to an outlet of the sample gas generation part (2) and for separating components included in the sample gas generated by the sample gas generation part (2), a detector (8) fluidly connected to an outlet of the separation column (6) and for detecting the components separated in the separation column (6), a plurality of gas supply sources (12A; 12B) for supplying gases serving as carrier gas for delivering the sample gas generated by the sample gas generation part (2) to the separation column (6), a switching part (14) to which the plurality of gas supply sources (12A; 12B) are fluidly connected and is configured to fluidly connect one of a plurality of the gas supply sources (12A; 12B) to the sample gas generation part (2) selectively by switching, a gas type setting part (44) configured to set types of gases supplied from each of a plurality of the gas supply sources (12A; 12B) connected to the switching part (14) based on information input by the user, a gas type memorizing part (36) configured to memorize an information as to types of gases set by the gas type setting part (44), and a gas type identification part (32) configured to recognize a state of the switching part (14) and to identify a gas type of the carrier gas supplied to the sample gas generating part (2) based on the state of the switching part (14) and the information memorized by the gas type memorizing part (44).

A liquid chromatograph inc es: an analysis column; a sample loop that temporarily contains a mixed liquid of a sample and a mixture solvent; and a passage switch valve capable of switching a passage between a load position where the mixed liquid is temporarily held in the sample loop and an injection position where the mixed liquid held in the sample loop is sent to the analysis column. In the liquid chromatograph, a specific passage is formed in each of the load position and the injection position.

A gas sampler (30) is provided with a connection portion (C1) connectable to a sample tank (20), a sample loop (PL) for holding a sample gas introduced from the sample tank (20) to the connection portion (C1), pneumatic switching valves (V1 to V6) for switching a flow path connected to the sample loop (PL), a control piping (81) for transmitting a driving pressure to the switching valves (V1 to V6), a pump (31) for suctioning an inside of the sample loop (PL), and a pressure accumulation tank (80) for accumulating the pressure generated by the operation of the pump (31) as a source pressure.