A method and system for sample analysis involve a temporally-resolving separation of sample components. In the method, solvent vapors are condensed prior to entering a temporally-resolving separator, a GC column, for example, and solvent-depleted vapors are directed to the separator where constituents are resolved in time. A system for analyzing a sample comprises an injection port, a temporally-resolving separator (e.g., a GC column) and a conduit connecting the two. The injection port is at a temperature sufficiently high to vaporize the solvent and analytes present in a sample. The conduit is configured and/or operated to condense the solvent, while maintaining the analytes in the vapor phase.

Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.

Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.

A method and system for sample analysis involve a temporally-resolving separation of sample components. In the method, solvent vapors are condensed prior to entering a temporally-resolving separator, a GC column, for example, and solvent-depleted vapors are directed to the separator where constituents are resolved in time. A system for analyzing a sample comprises an injection port, a temporally-resolving separator (e.g., a GC column) and a conduit connecting the two. The injection port is at a temperature sufficiently high to vaporize the solvent and analytes present in a sample. The conduit is configured and/or operated to condense the solvent, while maintaining the analytes in the vapor phase.

One or more embodiments of the present disclosure include a gas-analysis system. The gas-analysis system may include a first valve, a gas-measurement device, and a second valve. The first valve may be between a sample-gas line and a sample-gas outlet. The first valve may be configured to either allow or prevent gas movement between the sample-gas line and the sample-gas outlet. The gas-measurement device operatively coupled to a testing-gas line. The second valve may be between the sample-gas line, a flushing-gas inlet, and the testing-gas line. The second valve may be configured to allow gas movement from one of the sample-gas line or the flushing-gas inlet to the testing-gas line.

The present disclosure relates to a method performed in an interface system, the interface system comprising a reactor and a reaction-product-separator, the method comprising: (a) guiding a liquid containing analytes to and through the reactor and causing a component comprised by the analytes to react to a reaction product in the reactor, to thus create a post-reactor liquid comprising the reaction product, (b) guiding the post-reactor liquid from the reactor to the reaction-product-separator and through the reaction-product-separator, and separating the reaction product from the post-reactor liquid, to thus create a post-separator fluid, and (c) guiding at least one rinsing liquid through at least one of the reactor and the reaction-product-separator. The present invention also relates to an interface system, wherein the system is configured to perform the method, wherein the interface system comprises the reactor and the reaction-product-separator.

Systems and methods for automatically packing resin into and unpacking resin from a reusable separation column for sample analysis are described. A method embodiment includes, but is not limited to, introducing a slurry of resin to a reusable sample separation column to pack the reusable column with resin; introducing a sample solution to the reusable sample separation column; and unpacking the resin from the reusable sample separation column with a flow of liquid unpacking reagent and gaseous material.

Embodiments of the present specification provide methods and systems for clearing a detector of contaminants or any other undesirable substances that may affect operation of detector. The methods and systems enable a clear-down mode to clear the detector after an alarm is detected during sampling by the detector. The clear-down mode may be enabled immediately upon detecting a substance of interest. Further, the clear-down mode is effective to increase and direct all air flow through the detector in order to maximally purge contaminants from the detector.

A liquid chromatography having an on-line cleaning function, comprising a first flow channel (L3), a second flow channel (L21), an analysis flow channel (L22) and waste liquid flow channels, further comprising a cleaning flow channel (L25), a direction switch valve (V1) and a multi-flow channel switch valve (V2), etc. The liquid chromatography changes the flow path of the liquid by changing the communication relationship between the two-position switch valves, thus realizes the on-line cleaning function for a first chromatographic column (C1), a middle chromatographic column (C2), a filter or a protector (B2) respectively, and realize the simultaneous on-line cleaning function for the first chromatographic column (C1) and the middle chromatographic column (C2).

A preparative purification apparatus capable of adjusting a mixing ratio of a mobile phase and an elution solvent contained in a solution to be collected. A liquid feeding unit which feeds an elution solvent to an inlet of a trap column; a flow path switching unit which selectively connects an outlet of the trap column to one of a waste liquid flow path or a recovery flow path; a liquid feed amount measurement unit; and a flow path control unit which performs a control such that the flow path switching unit is connected to the recovery flow path when the amount of the elution solvent fed to the trap column reaches a predetermined initial waste liquid amount, and thereafter, the flow path switching unit is connected to the waste liquid flow path at a timing of reaching a predetermined solution recovery amount.