A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

A liquid chromatography having an on-line cleaning function, comprising a first flow channel (L3), a second flow channel (L21), an analysis flow channel (L22) and waste liquid flow channels, further comprising a cleaning flow channel (L25), a direction switch valve (V1) and a multi-flow channel switch valve (V2), etc. The liquid chromatography changes the flow path of the liquid by changing the communication relationship between the two-position switch valves, thus realizes the on-line cleaning function for a first chromatographic column (C1), a middle chromatographic column (C2), a filter or a protector (B2) respectively, and realize the simultaneous on-line cleaning function for the first chromatographic column (C1) and the middle chromatographic column (C2).

An analytical system comprising a mass spectrometer and an ionization source. The analytical system further comprises an analytical fluidic system connectable to the ionization source for infusing samples into the mass spectrometer via the ionization source, a downstream pump fluidically connectable to the ionization source via the downstream valve, where the downstream pump is fluidically connected to a plurality of fluid containers comprising respective fluids, the fluids comprising a concentrated composition for calibrating the mass spectrometer and at least one diluent for diluting the at least one concentrated composition. The analytical system further comprises a controller configured to control the downstream pump to obtain at least one diluted composition by automatically mixing a concentrated composition with a diluent with a predetermined dilution factor, to infuse the diluted composition into the ionization source, to obtain a mass spectrum of the diluted composition and to execute a calibration of the mass spectrometer. A respective automated analytical method.

A gas analyzer system (100, 200, 300) and methods of reducing sample carryover in a gas sample selector (102, 202, 302), The gas analyzer system (100, 200, 300) includes a gas chromatograph (104, 204, 304) and a gas sample selector (102, 202, 302). The gas sample selector (102, 202, 302) includes a multi-position selector valve (130, 230, 330), a flush valve (140, 240, 340), and a purge valve (150, 250, 350), as well as conduits providing flowpaths between them. When switching the flush valve (140, 240, 340) to connect the flush valve (140, 240, 340) vent and flush valve (140, 240, 340) outlet and flowing purge gas through the purge valve (150, 250, 350) port, the purge gas will flow to the selector (102, 202, 302) exit and to the flush valve (140, 240, 340) vent to remove sample gas from the flowpaths.

A gas component detection device includes a column, a sensor, a flow path, and a flow path switch. The column separates a component of gas to be detected. The sensor is, for example, a semiconductor sensor, is connected to the downstream side of the column, and detects a component of gas to be detected. The flow path connects the column and the sensor. The flow path switch is arranged between a flow path and a flow path. The flow path switch switches between and executes a measurement mode in which gas to be detected discharged from the column flows into the sensor, and a discharge mode in which gas to be detected discharged from the column is discharged to the outside.