A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

A method for evaluating drug responsiveness includes disposing a myocardial cell produced through differential induction onto a board including an electrode, administering a drug to the myocardial cell, continuously applying, after the drug is administered, a pulse current or a pulse voltage to the myocardial cell through the electrode for a certain period of time, measuring, after the certain period of time has elapsed, a pulsation characteristic of the myocardial cell, and evaluating responsiveness of the myocardial cell to the drug on a basis of the pulsation characteristic.

A method for monitoring a cell beating parameter, which includes adding excitable cells capable of beating to a system for monitoring cell-substrate impedance, the system having an electrode array electrically coupled to an impedance analyzer that measures cell-substrate impedance at millisecond time resolution, and a software program that determines a cell beating parameter from measured cell-substrate impedance; monitoring cell-substrate impedance of the excitable cells; and determining the cell beating parameter from the monitored cell-substrate impedance.

A measuring carrier for position-resolved meteorological determination of a measurement variable dependent on the dielectric permittivity of a device under test. The measuring carrier has a supporting means comprising a measuring surface, to which the device under test can be applied, and a measuring transmission line which entirely or partially forms the measuring surface and comprises a multiplicity of transmission line cells for the purpose of transmitting a radio-frequency measurement signal which can be injected at the input port. The measuring surface is structured in a cellular manner, wherein each of the transmission line cells has a cell-individual propagation constant with respect to the radio-frequency measurement signal in a state free of a device under test. This constant differs from the respective cell-individual constants of the other transmission line cells.

A biochemical sensing system senses interactions between molecular entities and nanopores using a sensor device comprising an array of sensor elements that support the nanopores. A switch arrangement selectively connects detection channels for amplifying sensed electrical signals to respective sensor elements. On the basis of an analysis of the amplified electrical signal output from the detection channels, detection of completion of interactions at sensor elements occurs. In response thereto, the switch arrangement is controlled to connect the detection channel connected to a sensor element at which completion of an interaction has been detected to a further sensor element.

An organ-on-chip device for monitoring a biological function and including a membrane layer located at an interface region between a top microchannel and the a microchannel. The membrane includes a first type of cells forming a barrier between the top microchannel and the bottom microchannel. The device further includes a top layer having a first plurality of transendothelial electrical resistance (TEER) measurement electrodes for enabling direct monitoring of cell function and electrical activity of the first type of cells on the membrane. The device also has a multi-electrode array (MEA) layer with a second plurality of TEER measurement electrodes for enabling direct monitoring of cell function and electrical activity of a second type of cells on the MEA layer.

The present disclosure relates to a cell potential detection apparatus that can prevent a culture solution from being contaminated by a component harmful to cells, a method for manufacturing the cell potential detection apparatus, and an information processing system. The cell potential detection apparatus includes a cell potential detection chip including an electrode section configured to detect a potential of a cell, a member included in a liquid storage section configured to store a culture solution for the cell, and a film covering a liquid contact surface of the member and being harmless to the cell, the liquid contact surface being configured to contact the culture solution. The present technology can be applied to, for example, a semiconductor module in which a chip for detecting a potential at an action potential generation point generated due to a chemical change in a cell is packaged.

Mechano-node-pore sensing (mechano-NPS), is a rapid, multi-parametric cell screening method that simultaneously quantifies cell diameter, transit time through a contraction channel, transverse deformation under constant strain, and recovery time after deformation.

Disclosed are a pipette type patch clamp, a measuring device having the patch clamp, and a method of manufacturing the patch clamp. The pipette type patch clamp includes a pipette type puller having a through region with a predetermined length such that an object is sucked therethrough, a silicon wafer configured to support the puller, an insulating layer disposed on a surface of the silicon wafer and a surface of the puller, and an electrode layer disposed on a surface of the insulating layer to connect to a first fluid channel and a second fluid channel.