A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.

The present invention relates to a simultaneous analysis method for a target using a plurality of metal nano-tags and, more particularly, to a simultaneous analysis method for a target using a plurality of metal nano-tags, wherein the method fuses a nano-particle technology on the basis of an antigen-antibody reaction, which is a conventional biological immune response, and simultaneously diagnoses a plurality of target materials by using a plurality of antigen-antibody reactions and a plurality of metal nano-tags, thereby enhancing diagnostic effect.

One aspect of the present disclosure relates to a device for detecting a pathogen biomarker in a biological sample. The device can comprise a substrate. The substrate can comprise paper. The device can also comprise a hydrophobic material applied to the substrate to define at least one target region, a sample region, and at least one channel in fluid communication with the at least one target region and the sample region. The device can further include a predetermined amount of antibodies that specifically bind to at least one pathogen biomarker provided in the at least one target region. The predetermined amount of antibodies is conjugated with colloidal gold.

The present invention relates to a reusable optical fiber aptasensor using a photo-thermal effect, and more particularly, to a reusable optical fiber aptasensor using white light and a laser. The aptasensor includes a light emitting unit for selectively emitting one of white light and a laser, a sensor unit including a plurality of aptamers, a plurality of gold nanorods, and a silver mirror, a detector for analyzing a wavelength of inputted light, and an optical fiber for connecting the light emitting unit with the sensor unit, and connecting the detector with the sensor unit, wherein the light emitted from the light emitting unit is totally reflected in the optical fiber and irradiated to the sensor unit, and light reflected from the silver mirror of the sensor unit is irradiated to the detector. Accordingly, the aptasensor easily measures concentration of a target material in a sample using the optical fiber.

Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.

The present disclosure relates to porphyrin containing carbon quantum dots useful for bioimaging and/or phytodynamic therapy.

Magnetic-optical iron oxide-gold core-shell nanoparticles are disclosed. Methods for making and using the nanoparticles are also disclosed.

The present invention relates to a core/shell nanoplatelet and its use as a fluorophore or a fluorescent agent.

One aspect of the present disclosure relates to a device for detecting a pathogen biomarker in a biological sample. The device can comprise a substrate. The substrate can comprise paper. The device can also comprise a hydrophobic material applied to the substrate to define at least one target region, a sample region, and at least one channel in fluid communication with the at least one target region and the sample region. The device can further include a predetermined amount of antibodies that specifically bind to at least one pathogen biomarker provided in the at least one target region. The predetermined amount of antibodies is conjugated with colloidal gold.

Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.