Methods and techniques for controlled printing of a cell sample for karyotyping are provided. The methods can involve matrix printing using on-the-fly printing or dispensing to accurately spread cells within at least one cell sample on a surface in preparation for karyotyping, and further analysis. Advantageously, the methods result in a uniform distribution of chromosomes of the cell suspension or sample on the surface of a substrate which can be substantially discretely identified, and also provide for efficiency in a subsequent staining process and any further analysis of the stained chromosomes using a microscope or other imaging device.

An electrolyte analyzing device with which an electrical effect does not occur has a housing to which a reference potential is applied and a flow passage which is electrically insulated from the housing. The analyzing device delivers a sample solution to a first electrode, and delivers a reference electrode solution to a second electrode. A reagent vessel placement unit which is electrically connected to the housing, has placed thereon a diluent bottle accommodating a diluent, an internal standard solution bottle accommodating the internal standard solution, and a reference electrode solution bottle accommodating the reference electrode solution. The reagent vessel placement unit includes a suction nozzle comprising an electrical conductor which is joined to the flow passage, and which can be inserted into and removed from each of the diluent, internal standard solution and reference electrode solution bottles. And, an insulator electrically insulates the suction nozzle and the housing.

The present invention relates to a method and a system (400) for filling a closed container (200) with a fixative solution. The system comprises a container (200) comprising a container body (230) for receiving a biological specimen, a lid (220) for selectively closing the container body (230) and a port (100) forming a unidirectional barrier in a direction from the inside (IC) to the outside (OC) of the closed container (200). The system further comprises a dispensing apparatus (500) having a filling nozzle (300) for dispensing the fixative solution. The filling nozzle (300) is relatively moveable with respect to the container (200) between a retracted position and a filling position to fill the container (200) with the fixative solution.

A reaction analysis system includes a first flow path through which a reaction fluid, obtained by mixing reactants in a mixer, flows, a second flow path through which the reaction fluid flows and that has higher heat exchange efficiency than the first flow path, a temperature measurer that measures a temperature distribution of the reaction fluid along the first flow path, and a reaction analysis device that specifies a reaction state of the reaction fluid based on a reaction parameter. The reaction parameter is obtained from the measured temperature distribution and indicates the reaction state of the reaction fluid.

Systems, devices, and methods for dispensing a of fluidic sample to each of a plurality of targets are disclosed. An example apparatus for dispensing a fluidic sample includes an inlet port to input a sample material, and a first sample nozzle and a second sample nozzle fluidically coupled to the inlet port to expel the sample material, wherein a tubular junction fluidically couples the inlet port to a first tubular fluid path that terminates in the first sample nozzle and to a second tubular fluid path that terminates in the second sample nozzle, wherein a cross-sectional area of the tubular junction is less than an average cross-sectional area of the first tubular fluid path and the second tubular fluid path, and wherein the cross-sectional area of the tubular junction is selected to draw the sample material from the inlet port into the tubular junction via capillary action.

An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.

There is provided an automated analysis device capable of transferring instruments to be used for an analysis process to a predetermined processing position efficiently and rapidly. In an automated analysis device of the invention, a transfer unit forming a transfer mechanism to transfer instruments to be used for analyte processing into an analyte processing space includes a holding portion to hold the instruments. The holding portion includes a first fitting attachment portion to be attachable to a first instrument in a fitted state, and a second fitting attachment portion to be attachable to a second instrument in a fitted state.

An autoclaving microplate washing system for cells and non-adhering three-dimensional (3D) cell cultures includes one or more peristaltic pumps for controlling the dispensing of washing fluid and the evacuation of fluid from microwells to gently wash the cells.

The present invention relates to a method and a system (400) for filling a closed container (200) with a fixative solution. The system comprises a container (200) comprising a container body (230) for receiving a biological specimen, a lid (220) for selectively closing the container body (230) and a port (100) forming a unidirectional barrier in a direction from the inside (IC) to the outside (OC) of the closed container (200). The system further comprises a dispensing apparatus (500) having a filling nozzle (300) for dispensing the fixative solution. The filling nozzle (300) is relatively moveable with respect to the container (200) between a retracted position and a filling position to fill the container (200) with the fixative solution.

A system may include a horizontal actuator to move a tray, to which a microwell plate and a microfluidic chip may be coupled. The system may include a vertical actuator to move a support arm, to which a plurality of pipettes or pipette tips may be coupled. The system may include a rotational actuator to move an angle bracket, to which a magnet may be coupled. The system may include a heater, through which the pipettes may extend. The system may include a pump to control the flow of fluids through the pipettes. Disclosed methods include performing PCR within the described system.