The present invention provides a nucleic acid aptamer specifically recognizing -lactoglobulin and use thereof. The nucleic acid aptamer has a sequence as shown in SEQ ID NO:1, a sequence having 60% or higher homology to the sequence as shown in SEQ ID NO:1 and specifically recognizing -lactoglobulin, or a sequence derived from the sequence as shown in SEQ ID NO:1 and specifically recognizing -lactoglobulin. The nucleic acid aptamer specifically binds to the allergen -lactoglobulin in cow milk and dairy products, thereby providing a new tool for the high-sensitivity and low-cost detection of the allergen -lactoglobulin.

The present invention relates to the use of hemopexin, free, non-cell bound fetal hemoglobin and alpha-1-micro-globulin as markers for preeclampsia.

The present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present invention also relates to in vitro kits for use in said methods.

The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.

The present invention relates to in vitro methods for aiding in the detection of hepatocellular carcinoma (HCC) in a subject comprising determining the amount of one or more glycan structure at position N207 of haptoglobin (i.e. of the -chain of haptoglobin having the sequence given in SEQ ID NO: 1) in a sample obtained from said subject. Also disclosed are a glycan structure as well as a glycopeptide comprising said glycan structure, both of great utility in the detection of HCC. Further, the present invention relates to the use of one or more glycan structure at position N207 or of a glycopeptide comprising N207 of haptoglobin in combination with AFP and/or PIVKA in the detection of HCC.

A milking arrangement comprising a milking machine for milking an animal, wherein the milking arrangement comprises a control unit that is configured to obtain identity of the animal in connection with milking of the animal, obtain a reference point in time of a lactation cycle of the identified animal, determine to take at least one milk sample of the animal, when a predetermined time period has passed from the reference point in time; obtain a Haptoglobin level from the milk sample, compare the obtained Haptoglobin level with a Haptoglobin reference limit, and indicate health condition of the animal, based on the made comparison.

Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

The present disclosure relates generally to biomarkers of fibrosis. More particularly, the present disclosure relates to salivary biomarkers and their use in methods, apparatuses, compositions and kits for determining an indicator that is useful for assessing a likelihood of a presence, absence or degree of liver fibrosis in a human subject. In particular embodiments, the disclosed methods, apparatuses, compositions and kits are used to determine an indicator for assessing a likelihood of a presence, absence or development of liver cirrhosis in a subject.