An apparatus to preserve a first fluid of a medicine vial is provided. The apparatus may include a vial coupling member comprising a housing and a flexible membrane. The housing and the flexible membrane form a vial coupling member cavity within the vial coupling member. The apparatus may also include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity. The apparatus may further include a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity. When the flexible membrane engages the medicine vial, the flexible membrane forms a sealed environment over a medicine vial septum. When the flexible membrane engages the medicine vial, the flexible membrane permits the first lumen and the second lumen to establish fluid communication with an interior space of the medicine vial.

The present invention relates to a method for manufacturing an ophthalmic preparation comprising thymosin 4. According to the inventive method, the manufacture of an ophthalmic preparation comprising thymosin 4 is carried out in the presence of an inert gas, thus the contact of thymosin 4 with oxygen is blocked and the oxidation of thymosin 4 can be prevented and the pharmacological activity of thymosin 4 maintains for long-term period. Therefore, the ophthalmic preparation prepared by the inventive method can maintain the pharmacological activity of thymosin 4 in a stable state for a long time.

A double-layer medical fluid bag includes an inner wall, an outer wall, clean air filled between the inner and outer walls, and a piercing device installed between the inner and outer walls. When it is necessary to use a liquid medicine contained in the medical fluid bag, the piercing device is moved forward to pierce a plate to be pierced, so that the clean air can enter into the inner wall slowly to push the liquid medicine to flow downwardly to the outside. During the operation and use processes, the liquid medicine is completely isolated from outside air, so as to avoid the danger of having unknown outside air to enter into the medical fluid bag and endure the safety of using the medical fluid bag.

A double-layer medical fluid bag includes an inner wall, an outer wall, clean air filled between the inner and outer walls, and a piercing device installed between the inner and outer walls. When it is necessary to use a liquid medicine contained in the medical fluid bag, the piercing device is moved forward to pierce a plate to be pierced, so that the clean air can enter into the inner wall slowly to push the liquid medicine to flow downwardly to the outside. During the operation and use processes, the liquid medicine is completely isolated from outside air, so as to avoid the danger of having unknown outside air to enter into the medical fluid bag and endure the safety of using the medical fluid bag.

An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

A reservoir assembly is disclosed. The reservoir assembly includes a reservoir; a port connector comprising: an inlet extending from an interior volume of the reservoir; an outlet wherein fluid contained in the interior volume of the reservoir exits the reservoir; and a filling port configured wherein the reservoir may be filled with a fluid.

A reservoir assembly is disclosed. The reservoir assembly includes a reservoir; a port connector comprising: an inlet extending from an interior volume of the reservoir; an outlet wherein fluid contained in the interior volume of the reservoir exits the reservoir; and a filling port configured wherein the reservoir may be filled with a fluid.