A hermetically sealed thermoplastic container or ampoule having a hollow body portion, a neck portion, unitary with the body portion and terminating in a circumferential flat sealing surface that defines an access aperture, and a removable cap. The neck portion is provided with an external thread and defines an access passageway to the hollow body portion. Part of the neck portion is configured as a tapered female connector adapted to receive a tapered male connector when the access passageway is open.

Aspects of the present invention are directed to an individual dose pack. The individual dose pack may comprise a single serving pod and an overwrap surrounding the entirety of the single serving pod and sealing the single serving pod therein, wherein the overwrap is child-resistant and creates an impermeable barrier being resistant to the passage of liquids and gases. The single serving pod may include a cup, at least one pharmaceutical active ingredient provided in the cup, and a lid affixed to the cup. The overwrap is a multi-layer structure including a first layer being a biaxially-oriented polyethylene terephthalate layer, a second layer being a polyethylene layer, a third layer being an aluminum foil layer, and fourth layer being an ionomer layer.

The invention relates to an apparatus for preparing ready-to-use solutions for peritoneal dialysis that has a sterilization compartment; a filling line leading to the sterilization compartment and having a connector arranged at its end at the compartment side for connecting a disposable; a water treatment system arranged in the filling line; and a sealing system. The invention further relates to a disposable for preparing ready-to-use solutions for peritoneal dialysis in such an apparatus and to a method of preparing ready-to-use solutions for peritoneal dialysis using such an apparatus and such a disposable.

The present disclosure relates to systems that rely on a self-locking cover to limit access to narcotics. A self-locking cover may allow for a single access opportunity to a narcotics vial, which may be one or both original vials and waste vials. In some aspects, a self-locking cover may be incorporated into narcotics transportation and tracking mechanisms, which may allow for increased security against tampering or abuse of narcotics, particularly narcotics waste. Self-locking covers may prevent uninhibited and free access to waste narcotics, which may be susceptible to abuse.

A container, consisting of an at least partially filled container body, and of at least one cap part (10), which has at least one sealing part (16) which, for removal of the container contents, can be penetrated by a hollow-spike-like insertion part (22) from the outside, with a predeterminable actuating force, in an introduction direction, it being possible for said insertion part to be removed from the container again, with a predeterminable pull-out force, in an oppositely directed pull-out direction, is characterized by the presence of a device (16, 18) which makes it difficult for the insertion part (22) to be removed and by means of which the pull-out force is increased such that unintentional removal of the insertion part (22) is at least made difficult.

The invention relates to a medical package designed as an infusion bag, which medical package is made from multi-layer films that are welded to one another and is filled with a medical liquid for infusion and/or for parenteral nutrition. The invention is described by a medical package designed as an infusion bag, which is made up of a film comprising multiple layers welded to one another and has at least one weld seam, preferably longitudinal and transverse weld seams, and is filled with a medical liquid. The multi-layer film has at least one inner layer of a matrix-phase polymer system, an intermediate layer of a matrix-phase polymer system, and an outer layer of a matrix-phase polymer system. The matrix polymer of the matrix-phase polymer system of the inner layer, the intermediate layer and the outer layer in each case comprises a polypropylene polymer (PP) having defined parts by weight in the individual layers, and the phase polymer of the matrix-phase polymer system of the inner layer, the intermediate layer and the outer layer in each case comprises a styrene-ethylene/butyl-styrene block copolymer (SEBS) having defined parts by weight in the individual layers. The film is characterised in that the styrene-ethylene/butyl-styrene block copolymer (SEBS) of the intermediate layer has a styrene-ethylene/butylene ratio (S/EB.sub.M) and the styrene-ethylene/butylene-styrene block copolymer (SEBS) of the outer layer has a styrene-ethylene/butylene ratio (S/EB.sub.A), in which S/EB.sub.A>S/EB.sub.M. It has been shown that in this way the mechanical properties of the multi-layer film can be improved, in particular in the event of expansion of the multi-layer film in the region of the weld seams. The improved mechanical properties appear both at room temperature and also at lower temperatures of down to 4? C.

A cap for a fluid container includes: (i) a body, (ii) a first port, and (iii) a second port. The first port includes a first port housing with a first opening and an elastic first seal member accommodated in the first port housing and sealing the first opening. The second port includes a second port housing with a second opening and an elastic second seal member accommodated in the second port housing and sealing the second opening. The first seal member is formed as a pierceable septum. The outer surface of the first seal member is flush with an edge surface of the first opening. The second seal member includes a valve opening configured to provide a fluid-tight connection with a fluid manipulation device.

A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A septum is located at least partially within the first opening and includes an aperture therethrough. The septum allows a blunt cannula to pass through the aperture to access the interior of the plasma storage container. The top also includes a hydrophobic membrane located on underside of the top body. The membrane covers the vent opening and allows air to vent through the vent opening during plasma collection.

A closure for a pharmaceutical vial. The closure comprises an aluminum foil with an inductively meltable adhesive, an elastic seal, and a cap. The cap has an opening through which a perforating cannula can be inserted.

A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the effects of the blow-fill sealing on the biopharmaceutical product, providing a parison to a blow-fill sealing machine for accepting the biopharmaceutical product during the blow-fill sealing, predicting a temperature of at least one the biopharmaceutical product, the parison, and a component of the blow-fill sealing machine at a stage in the blow-fill sealing, and adjusting a parameter of the blow-fill sealing machine to reduce damage to the biopharmaceutical product.