According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

A vial adaptor can include a connector interface and/or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and/or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

Methods and apparatus are disclosed for sterilizing raw hazardous medicine and the filling and capping syringes disposed within closed and sterile plastic bags to provide sterile medical preparations apart from laminar flow hoods and like equipment. Of particular note, such methods are particularly applied to providing syringes filled with sterilized hazardous drugs while reducing concern for unintentional spills and sterilizing medical preparations and filling large numbers of syringes with steps reduced by novel apparatus and methods. Also, a capping plate is disclosed which provides a method for capping a plurality of male syringe luer fittings by a single displacement step followed by facile release of cap and associated syringe from the capping plate for use in a medical procedure.

Methods and apparatus are disclosed for sterilizing raw hazardous medicine and the filling and capping syringes disposed within closed and sterile plastic bags to provide sterile medical preparations apart from laminar flow hoods and like equipment. Of particular note, such methods are particularly applied to providing syringes filled with sterilized hazardous drugs while reducing concern for unintentional spills and sterilizing medical preparations and filling large numbers of syringes with steps reduced by novel apparatus and methods. Also, a capping plate is disclosed which provides a method for capping a plurality of male syringe luer fittings by a single displacement step followed by facile release of cap and associated syringe from the capping plate for use in a medical procedure.

A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 ?m and the plug has a surface area of 30 mm.sup.2 to 2 mm.sup.2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 ?m.

The invention relates to a device for dispensing an aqueous liquid through an interface membrane made partially hydrophilic and partially hydrophobic, made so that when in operation, during each operation of dispensing a metered amount of liquid, the streams of air and liquid flow alternately in a capillary channel (18) downstream from the membrane. Said interface membrane (7) is made of a filtering material which includes biocidal metal cations in the body thereof. Said device comprises a porous insert (8), which is permeable both to liquid and to air, which is arranged upstream from the membrane in the path of the fluids and which is made of a material including sites with negative charges capable of attracting biocidal metal cations from said membrane.

The invention proposes a biological protection membrane which is mounted, in a device for dispensing liquid from a sterile packaging bottle, across a fluid-circulation duct, in the path of the liquid extracted from the bottle and the outside air which is drawn into the bottle. The membrane (7) is made partially of a hydrophilic material and partially of a hydrophobic material. Both the hydrophobic portion (23) and the hydrophilic portion (22) are made from a polymer base, laden in the body thereof with a biocidal agent that is active in the destruction of bacteria by the ionic oxidation effect. The circulation of fluids through the membrane (7) is organised so as to promote the ionic action on the flow of outside air in the hydrophobic material, and to drive the ionically charged active agent by the liquid passing through the membrane in the hydrophilic portion thereof. A porous buffer (8), inserted in the path of the fluids on the inside of the membrane, collects the active agent extracted from the membrane by the remaining liquid not dispensed, passing through the membrane from the outside towards the inside.

A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

A container adapted to store and transport an injectate is disclosed. The container includes a divider which extends from an open top end toward a closed bottom end, the divider spaced apart from the closed bottom end to define an opening and separating the container into a first fluid path on a first side of the divider through which fluid can enter the container through the inlet port and a second fluid path on a second side of the divider through which fluid can enter the opening and exit the container through the outlet port. The second fluid path includes at least one filter between the opening and the open top end through which fluid can pass from the first fluid path to the second fluid path but through which at least one component of the injectate cannot pass.