A method for determining a quantitative result CT parameter map in a region of interest of an object under examination is described. The method includes acquiring a sequence of quantitative input CT parameter maps for at least two predetermined times, the sequence being generated by a contrast-enhanced spectral multiphase CT of the region of interest; receiving a sequence of contrast-enhanced MRI image datasets, the MRI datasets having a higher temporal resolution than the sequence of input CT parameter maps; determining a relation between the MRI image datasets and the input CT parameter maps; and determining the result CT parameter map based on the determined relation and the MRI image datasets for at least one additional time, the at least one additional time being different from the predetermined time.

An imaging apparatus has an MRT system with an MR receiving antenna configured to receive a first receive signal containing an MR signal from an object to be examined during an examination period. The imaging apparatus includes a modality for examining the object and/or for acting on the object via mechanical or electromagnetic waves, wherein the modality has an electronic circuit. The imaging apparatus includes an auxiliary antenna arranged and configured to receive a second receive signal containing an interference signal generated by the electronic circuit during the examination period. The imaging apparatus has a processing system configured to suppress interference in the first receive signal based on the first and the second receive signal.

A method for generating transmission information in a time-of-flight positron emission tomography (PET) scanner having a patient tunnel and a plurality of PET detector rings. The PET scanner uses continuous bed motion to move a patient bed and patient through the patient tunnel. The patient receives a positron-emitting radioisotope dose prior to undergoing a PET scan. The method includes storing a positron-emitting radioisotope in a radiation shielded container. The method also includes moving the radioisotope into a stationary vessel located adjacent to the PET detectors and within a field of view of the PET scanner at substantially the same time that the patient receives the radioisotope dose to form a stationary transmission source wherein transmission information is generated while the bed undergoes continuous bed motion. Further, the method includes withdrawing the radioisotope from the vessel when the PET scan is complete and storing the radioisotope in the container.

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

The invention relates to quality control devices and methods for magnetic resonance imaging (MRI) systems, more particularly for medical imaging applications. An example is stereotactic surgery where MRI images are combined with X-ray images to accurately locate a target in a subject. A test device (1), and an associated method using said test object, are used to easily detect a faulty calibration or a malfunction of an MRI device. The test device includes: a hermetically sealable hollow body (20) having a substantially cylindrical shape, a support frame (22) configured to be removably inserted in the hollow body and defining a target region (V22) having a substantially cylindrical shape; and a plurality of target objects (24) made of a material visible on X-ray images and MRI images said target objects being arranged in the target region and being attached to the support frame.

Disclosed herein is a medical system (100, 300, 500) comprising a processor (104) configured for controlling the medical system and a memory (110) for storing machine executable instructions. Execution of the instructions causes the processor to receive (200) four-dimensional Dixon magnetic resonance image data (122). The four-dimensional Dixon magnetic resonance imaging data is T1 weighted. The four-dimensional Dixon magnetic resonance image data is synchronized to a respiratory signal (124). Execution of the instructions further causes the processor to reconstruct (202) synthetic four-dimensional computed tomographic image data (12) from the four-dimensional Dixon magnetic resonance imaging data. The four-dimensional Dixon magnetic resonance imaging data is synchronized to the respiratory signal.

Disclosed is a computer-implemented method for determining an orientation of an electrode using acquired two-dimensional rotational images taken while the two-dimensional imaging apparatus is rotated about the patient, and acquired three dimensional tomographic images of the anatomical structure. The electrode orientation is determined in the three-dimensional reference system of the tomographic imaging apparatus.

The invention provides for a medical imaging system (100, 300) comprising a processor (106) for controlling the medical imaging system. Execution of machine executable instructions (112) causes the processor to receive (200) a static angiographic image (114) of a region of interest (322), receive (202) a time series of angiographic images (116, 116′) of the region of interest, construct (204) an image mask (118) using the static angiographic image, determine (206) a time dependent signal (120) for each voxel within the image mask using the time series of angiographic images, construct (208) a composite angiographic image by: assigning (210) a fill time (126) to each voxel within the image mask using an extremum (124) of the time dependent signal if the extremum deviates from an average of the time dependent signal more than a predetermined threshold, and identifying (212) voxels within the image mask as being unfilled voxels.

The present disclosure relates to a method for converting magnetic resonance imaging (MRI) to a computed tomography (CT) image using an artificial intelligence machine learning model, for use in ultrasound treatment device applications. The method includes acquiring training data including an MRI image and a CT image for machine learning; training an artificial neural network model using the training data, wherein artificial neural network model generates a CT image corresponding to the MRI image, and compares the generated CT image with the original CT image included in the training data; receiving an input MRI image to be converted to a CT image; splitting the input MRI image into a plurality of patches; generating patches of a CT image corresponding to the patches of the input MRI image using the trained artificial neural network model; and merging the patches of the CT image to generate an output CT image.

This invention relates to disease detection by imaging and treatment of virus infection. Previously, there was no way to use CEST MRI imaging to early detect and map the neurodegenerative diseases, multiple sclerosis disease, concussion, and traumatic brain injury. Also, previously, there was no way to use Computed Tomography (CT) imaging to early detect and map the neurodegenerative diseases. Embodiments of the present invention use a non-invasive CEST MRI imaging method is disclosed for early detection of diseases by using MRI or by using CT. The endogenous (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of the neurodegenerative diseases, multiple sclerosis disease, concussion, traumatic brain injury, and other diseases by using endogenous protons contrast via CEST MRI. Also, the exogenous agents can be used to produce MRI contrast, such as agents contain exchangeable protons and thereby provide imaging and mapping the inflammation in cancer and the expressed proteins in cancer cells for cancer detection. Also, using exogenous CT contrast agents for detection of amyloid beta, tau protein, alpha-synuclein protein, and aggregation proteins in neurodegenerative diseases and inflammation in many diseases such as neurodegenerative diseases, cancer and other inflammatory diseases Also, this invention relates to novel methods of treatment virus infection and enhance the immune system to produce antibodies against the viruses.