The invention relates to a rocuronium composition providing no or less vascular pain to patients upon injection. The rocuronium composition has a pH of 2.5 to 3.5 and a titratable acidity of not more than 35 mEq. The rocuronium composition is stable upon thermal sterilization. Further, the rocuronium composition is stable upon storage at room-temperature.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Fluid transfer couplings or connectors including dual function press-in bottle adaptors supporting different syringe types, connectors having a universal port for supporting different syringe types, transfer couplings compatible for use with different syringe types. Other caps and closures incorporating couplings for fluid transfer with different syringe types is also disclosed.

A system for the closed transfer of fluids that provides substantially leak-proof sealing and pressure equalization during engagement of a cannula with a vial, during transfer of a substance from a vial chamber to a barrel chamber via the cannula, and during disengagement of the cannula from the vial is disclosed. The leak-proof sealing of the system substantially prevents leakage of both air and liquid during use of the system. The system of the present disclosure also permits pressure equalization between a vial and the system when the system is attached to the vial. The system is compatible with a needle and syringe assembly for accessing a medication contained within a vial for administering the medication to a patient.

A system includes a vial access device including a spike, with the vial access device attachable to a first vial defining a first vial size, and an adapter transitionable between a shield position in which the adapter is attachable to the vial access device such that the adapter shields the spike of the vial access device and a vial position in which the adapter is attachable to a second vial defining a second vial size, the second vial size different than the first vial size.

A septum holder having a body. The body has a disk shaped annular upper body part and a lower body part, at least one resilient elongated arm terminating with a distal enlarged element attached to the side of the body, and a septum fitted into the lower body part so that it extends downward parallel to the at least one arm. The septum is made of a single piece of cylindrically shaped resilient material. The upper part of the septum has a diameter larger than the middle part of the septum in order to form a flange that rests on an annular ledge created around the inside of the bottom section of the body when the middle part of septum slides through the open center at the bottom of the bottom section. The lowest part of the septum has a diameter that matches that of a septum in a fluid transfer component. The septum has a cavity created in its middle part into which an insert having at least one bore that functions as the seat of a needle valve is inserted.

A drug transfer adapter includes a body having a first end and a second end positioned opposite the first end, a transfer spike extending from the body and defining an opening, with the transfer spike configured to pierce a closure of a container, a connector extending from the body, and a securing member extending from the body. The securing member has a first side and a second side positioned opposite the first side, with the first side of the securing member including an adhesive surface configured to secure the body to a container.

A vial adapter for reconstituting a drug and drawing a drug from a vial. The vial adapter includes a passageway for passage of a diluent into the vial to mix with and reconstitute the drug and a chamber containing the reconstituted drug drawn from the vial. A vacuum is applied through the adapter to draw the reconstituted drug from the vial. The reconstituted drug can be accessed in one or two ways, either via a luer locked syringe or via a needled syringe.

A method for performing a medical procedure requiring effective, reliable and foolproof delivery of controlled amounts of a medical grade gas to a patient includes providing a compressed gas cylinder having a weight with medical grade gas sealed therein of at least twelve grams and not greater than fifty grams. The method also includes connecting the compressed gas cylinder to an integrated compressed gas unit including a regulator valve assembly positioned between an outlet port and an inlet port, wherein the regulator valve assembly includes a press button actuator and regulator adjustment dial. A flow control system is secured to the compressed gas unit and the medical grade gas is delivered in precisely controlled amounts by actuating the compressed gas unit and operating the flow control system to deliver the medical grade gas to vasculature of the patient.

A medical system is disclosed. The medical system has a housing and a module received in the housing. The module includes an analyte sensor configured for detecting an analyte in a body fluid of a user, an electronics unit electrically connected to the analyte sensor, an insertion component configured for inserting the analyte sensor into body tissue of the user, and a sterility cap at least partially surrounding the insertion component. A removable protective cap is connected to the housing and covers the module. The protective cap at least partially surrounds the sterility cap. The sterility cap has a sterility testing access that has at least one of a septum and a multiple-step sealing. A method of sterility testing the medical system is also disclosed in which a rinsing liquid is inserted into an interior space of the sterility cap and microbial testing of the rinsing liquid is then completed.