A method of manufacturing a capsule 12 for holding a substance 14 including providing a capsule body 2 having a closed end 5, an opposed open end 6 and a predetermined length defined between the ends 5, 6; providing a diaphragm 4 having a closed end 7, an opposed open end 8 and a predetermined length defined between the ends 7, 8; partially filling the body 2 with substance 14; inserting the closed end 7 of the diaphragm 4 into the open end 6 of the body 2 such that regions of the body 2 and the diaphragm 4 overlap one another with the open ends of the capsule body 2 and the diaphragm 4 being flush, thereby closing off the open end 6 of the body 2 and defining a chamber 104 within which the substance 14 is held; and heat welding the flush ends of the body 2 and the diaphragm 4 to one another to hermetically seal the chamber 104.

The present invention relates to a capsule device and a pharmaceutical dosage form using the capsule device for application to a mucous membrane, in particular to a buccal, intestinal, rectal or vaginal mucous membrane, comprising at least one string-like or strip-like preparation comprising the active pharmaceutical ingredient, the dosage from consisting a first and a second halve-capsule shell, and a hollow cylindrical wall part which jointly define the size of an aperture for releasing the preparation. The invention also relates to a method of producing the pharmaceutical dosage form.

Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

A tamperproof dosage form for oral administration comprising a cap and a body each comprising an outer surface and an inner surface, the cap and body being arranged to telescopically engage with each other such that an overlap region is 5 formed between a portion of the outer surface of the body and a portion of the inner surface of the cap, said overlap region comprising an overlap length extending parallel to a centerline of said dosage form, wherein an adhesive substance is comprised throughout substantially the entire overlap length bonding said cap to said body.

A tamperproof dosage form for oral administration comprising a cap and a body each comprising an outer surface and an inner surface, the cap and body being arranged to telescopically engage with each other such that an overlap region is formed between a portion of the outer surface of the body and a portion of the inner surface of the cap, said overlap region comprising an overlap length extending parallel to a centerline of said dosage form, wherein an adhesive substance is comprised throughout at least a portion of the overlap length bonding said cap to said body. The adhesive substance being essentially free of organic solvent.

Present invention relates to a capsule sealing composition and the method of using said composition for sealing capsules. Said sealing composition contains an acidic or alkaline solute and a volatile solvent; said sealing method uses the characteristics of capillary action ad volatile solvents to dissolve and seal the junction of the capsule cover and capsule body and said capsule then becomes a sealed capsule and the drugs contained in the capsule will not leak easily.

A tamperproof dosage form for oral administration comprising: a caplet comprising first and second ends, a middle region extending between said first and second ends, parallel and oppositely disposed top and bottom faces, and a land interposed between the top and bottom faces and extending along a perimeter of the caplet on a plane parallel to a caplet length axis; and first and second shells, each comprising an open end and a closed dome-shaped end, each fitted over at least a portion of the caplet, the portion comprising at least the first and/or second ends of the caplet and at least part of the middle region. An adhesive substance being arranged between the caplet and the shells at least over a portion of the top and/or bottom faces proximal to the first and second ends of the caplet and a corresponding portion of an inner surface of the closed dome-shaped end of the shells to fixedly join the shells to the caplet.

A tamperproof dosage form article comprising: a core, wherein the core comprises a first end and a second end; a first shell on at least a portion of the first end of the core; a second shell on at least a portion of the second end of the core; wherein the first and second shells comprise one or more locking protrusions extending along at least a portion of the circumference and inner surface of the shells, and the core comprises one or more locking recesses, and wherein at least a portion of the shells proximal to the locking protrusions is elastically deformable and arranged such that each one locking protrusion is snapped into each one of the locking recesses once inserted over a predetermined portion of the core to provide a locking force between the core and the shells.

The present invention relates to a device for dispensing a single droplet of a fluid, for example a single droplet of an adhesive, onto the inside surface of a cap or onto the inside surface of a body of a capsule, this is useful for rendering a closed capsule with a telescopically engaged cap and body more tamperproof, or for fixing a cap or a body or both, which encloses a caplet or tablet or a part thereof, to the caplet or the tablet.

A viscous liquid supply apparatus includes a storage tank (10) that stores viscous liquid, and a pump (14) that supplies the viscous liquid stored in the storage tank to a use point, wherein the viscous liquid supply apparatus is configured with a viscometer (20) that measures a viscosity of the viscous liquid stored in the storage tank, and a replenishment device (30) that supplies replenishment liquid to the storage tank based on the viscosity measured with the viscometer. The viscometer (20) is a rotary type viscometer that has a rotor (23) in a cylindrical shape wherein the rotor is immersed in the viscous liquid and rotates therein, and the rotor is configured with a stirring blade that agitates the viscous liquid inside the storage tank (10).