Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication.

A system and method for determining an optimal combination drug product for a particular patient includes a processor that receives patient information and determines an optimal combination drug product based on the received information. A system which can provide information regarding predicted events or pathologies based on received patient information and guidance on subsequent steps to ameliorate, treat or intervent. A drug production device includes a plurality of drug containers, each of which are coupled to a drug dispensing channel. A controller controls the dispensing of drug through each channel, and a combination drug product is produced from the dispensed drugs. A combination drug product includes a plurality of discrete units of a first drug, and a plurality of discrete units of a second drug. A transdermal patch includes a plurality of drug compartments, each containing a quantity of drug product, and a controller for controlling the release of drugs from each compartment. Feedback loop elements can enable iterations to optimized personalized doses.

A filling machine for filling capsules a product comprises a plurality of operative stations for carrying out operations on the capsules, a movement device provided with seats for housing and moving the capsules through the operative stations; and a weighing station to weigh of the capsules and comprising a weighing unit and a transfer system to transfer the capsules from the movement device to the weighing unit and vice versa. The weighing unit comprises a gripping element coupled with a weighing cell and provided with a housing for receiving and holding the capsule to be weighed. The transfer system include a first transfer element to remove the capsule from the seat of the movement device and insert it in the housing to measure its weight, and a second transfer element to remove the body from the housing and insert it in the seat of the movement device, after the measurement.

A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm.sup.2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Disclosed is a capsule filling apparatus. The capsule filling apparatus includes a supplying member configured to supply a tablet; a moving member configured to move the tablet supplied from the supplying member in a preset direction; a catching member configured to catch the tablet moved by the moving member by suction and insert the caught tablet into a capsule; and a capsule accommodating member located below the catching member so that the capsule is accommodated therein.

The present invention relates to a tamping system (100) for tamping of filler materials of capsule filling machine to form slug, and selectively delivering the slug from a dosing disc (108) based on the presence/absence of empty capsule bodies in an empty capsule segment in a turret of capsule filling machine. The tamping system (100) based on the presence/absence of empty capsule bodies in the empty capsule segment, enables actuation of pneumatic cylinders (113) to restrict movement of tamping pistons (110) into the respective holes of the dosing disc (108) that were configured to be align with the empty capsule segments of the turret where no capsule bodies were identified or present, irrespective of the downward movement of the holder blocks (111) towards the dosing disc (108), thereby restricting the delivery of the slug into empty capsule segment of the turret, and preventing wastage of the filler material or slug.

The invention provides a rotary die mold process for manufacturing softgel capsules incorporating another solid form within said capsule and wherein said softgel capsule is free of air bubbles, in which at least two material strips are brought together by means of counter-running forming rolls and formed into capsules, a liquid and solid filling material being introduced via a filling wedge segment comprising two concave wedge surfaces; a filling medicine inlet; a fill medicine outlet; an output of solids and pre-fill medicine; a solids feed channel and pre-fill medicine; a pre-filling medicine inlet and a solids inlet. A softgel capsule free of air bubbles having incorporated within said capsule a second solid form, said second solid form being the form of a tablet.

A composition for eliciting a T-cell mediated immune response in a subject includes transfer factor from at least two different types of source animals. For example, the composition may include mammalian transfer factor and nonmammalian transfer factor. An example of the composition includes a combination of a colostrum-derived product, which includes the mammalian transfer factor, and an egg-derived product, which includes the nonmammalian transfer factor. Additionally, the egg-derived product may be substantially free of fat. Methods for forming the composition and eliciting T-cell mediated immune responses in subjects that have been treated with the composition are also disclosed.

A dispenser (100, 500, 900) for granules is disclosed herein. In a specific embodiment, the dispenser comprises a granular reservoir (1); a selector disk comprising (a) a feeder disk (2, 22, 52) comprising at least one protruding member (3, 23); and (b) a dispensing disk (8, 58) arranged to rotate in concert with the feeder disk (2, 22, 52). The dispensing disk further comprises at least one dispensing aperture (9) and a non-dispensing portion (103), the at least one dispensing aperture (9) being in registration with the at least one protruding member (3, 23). The dispenser (100, 500, 900) further comprises a holding disk (4, 94) comprising at least one through-hole (5) sandwiched between the feeder disk (2, 22, 52) and the dispensing disk (8, 58) and fixedly mounted with respect to the granular reservoir (1), wherein the selector disk is rotatable relative to the holding disk (4, 94) and the granular reservoir (1) between a first position in which the at least one protruding member (3, 23) is offset from the at least one through-hole (5) to allow a granule to be received from the granular reservoir and held within the at least one through-hole (5) by the non-dispensing portion (103) of the dispensing disk (8, 58) and a second position in which the at least one protruding member (3, 23) occludes the at least one through-hole (5) to allow the granule held in the at least one through-hole to dispense through the at least one dispensing aperture (9). Methods of dispensing granules using the dispenser (100, 500, 900) are also disclosed.

A device for the dosed filling of a container with a filling material has a holding unit for holding the container and a filling unit by which a defined amount of filling material is withdrawn from a material store and transferred into the container. The filling unit has a dosing chamber. The dosing chamber is mounted displaceably alternately between a first position and in a second position. In its first position, the dosing chamber is in contact with the material store so that filling material can be transferred out of the material store into the dosing chamber. In its second position, the dosing chamber is situated above the container so that the filling material in the dosing chamber can be emptied into the container. The material store is in the form of a separate container and can be fastened detachably to the device by a fastening unit.