In some aspects, the described systems and methods provide for a method comprising transmitting to a brain of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain, with the at least one transducer, data acquired from the brain including information related to standing waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, intracranial pressure of the person.

In some aspects, the described systems and methods provide for a method comprising transmitting to a skull of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the skull, with the at least one transducer, data acquired from the skull including information related to guided waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, intracranial pressure of the person.

In some aspects, the described systems and methods provide for a method comprising transmitting, with at least one transducer, acoustic signals to a brain of a patient, wherein the at least one transducer is configured to induce excitation of a plurality of acoustic modes. The method further comprises receiving, with the at least one transducer, data acquired from the brain including information related to standing waves, frequency response, impulse/transient response, and/or distribution of acoustic modes. The method further comprises determining, from the acquired data, a distribution of intracranial pressure within the brain of the person.

In some aspects, the described systems and methods provide for a method comprising transmitting to a brain of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain, with the at least one transducer, data acquired from the brain including information related to standing waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises detecting, from the acquired data, a seizure of the person.

In some aspects, the described systems and methods provide for a method comprising transmitting to a brain and/or skull of a patient, with at least one transducer, acoustic signals. The method further comprises receiving from the brain and/or skull, with the at least one transducer, data acquired from the brain and/or skull including information related to standing waves, guided waves, distribution of acoustic modes, frequency response, and/or impulse/transient response. The method further comprises determining, from the acquired data, presence of a tumor within the brain of the person.

In some aspects, the described systems and methods provide for a method comprising transmitting, with at least one transducer, acoustic signals to a brain of a patient, wherein the at least one transducer is configured to induce excitation of a plurality of acoustic modes. The method further comprises receiving, with the at least one transducer, data acquired from the brain including information related to standing waves, frequency response, impulse/transient response, and/or distribution of acoustic modes. The method further comprises determining, from the acquired data, a location of a seizure site within the brain of the person.

A transducer array (302) for an ultrasound imaging system (300) includes a row-column addressed 2-D array of transducer elements (304). The row-column addressed 2-D includes a first array of 1-D arrays of elements, a second array of 1-D arrays of elements, which is orthogonal to the first array, and a double-curved surface (306). In another aspect, an apparatus includes a transducer array with an array-wise addressable 2-D array with a curved surface. The 2-D array includes a set of 1-D column array elements and a set of 1-D row array elements. The apparatus further includes transmit circuitry (308) that conveys an excitation pulse to the transducer array, receive circuitry (308) that receives a signal indicative of an ultrasound echo from the transducer array, and a beamformer (314) that processes the received signal, generating ultrasound image data.

A system and method for determining tissue changes. Shear waves are transmitted across the tissue in response to an ultrasonic signal input exterior to the tissue surface. Adaptive beam forming signal processing is applied to signal returns and arrivals to remove distortions by targeting velocity contrasts. Shear-wave dispersion, such as due to viscosity and mass changes in the tissue, are then estimated and compared to reference data to determine tissue health.

A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e., concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.

An ultrasonic sensor includes a substrate, a platen and an acoustic stack disposed between the substrate and the platen, including at least one piezoelectric layer. The ultrasonic transducer exhibits a signal-to-noise ratio of at least 4 over a frequency range of at least 9 to 16 MHz.