A biocompatible column for concurrent micro-positron emission tomography (micro-PET) or micro-single photon emission computed tomography (micro-SPECT) of at least two cell cultures is provided, the column having an inlet, an axially oriented perfusion chamber and an outlet, wherein the perfusion chamber includes a porous solid phase with sponges having biopolymer (such as silk, silk fibroin, collagen, gelatin, agarose, alginate, polylactic acid, agar, or methyl-cellulose), an aqueous liquid phase, a first cell culture and a second cell culture, wherein the first cell culture and the second cell culture are in contact with the solid phase and wherein the first cell culture is separated from the second cell culture by the solid phase. Also provided is a method and a kit for concurrent micro-PET or micro-SPECT of at least two cell cultures.

A method for determining an abnormality score map for Single-photon Emission Computed Tomography (SPECT) gamma camera flood analysis includes extracting a plurality of image patches from an input flood image and generating a feature vector for each image patch. A per-patch abnormality score is generated for each feature vector by comparing the feature vector against a normal flood feature dictionary comprising one or more normal flood feature vectors generated using a plurality of normal flood images. Then, an abnormality score map may be generated to depict the per-patch abnormality scores for the input flood image.

The present disclosure provides an imaging system and method for nuclear medicine imaging. The imaging system may include a detector and a collimator. The detector may be configured to detect photons. The collimator may have at least two sets of pinholes. The at least two sets of pinholes may include a first set of first pinholes and a second set of second pinholes. Each second pinhole of the second set of second pinholes may be equipped with a filter configured to filter the photons.

Provided is a device for spectrometry of a radiation of photons, including a detector configured to receive the radiation and to deliver, at an output, an electrical signal that is a function of the radiation (X) received, a reference database that can be parameterised by means of a first parameter, a comparator configured to establish a comparison between the electrical signal and the reference signal, the comparator delivering a signal (E(t)) representative of the energy of each photon of the radiation and a quality factor (B(t)) of the comparison, and a feedback loop enabling the first parameter of the reference database to be adapted so as to optimise the quality factor (B(t)).

Various aspects include methods compensating for Compton scattering effects in pixel radiation detectors. Various aspects may include determining whether gamma ray detection events occurred in two or more detector pixels within an event frame, determining whether the detection events occurred in detector pixels within a threshold distance of each other in response to determining that detection events occurred in two or more detector pixels within the event frame, and recording the two or more detection events as a single detection event having an energy equal to the sum of the measured energies of the two or more detection events located in the detector pixel having a highest measured energy in response to determining that the detection events occurred in detector pixels within the threshold distance of each other.

The present disclosure relates to a PET detector module suitable for using in a PET/MR hybrid system. The PET detector module comprises a scintillator, a set of frontend electronics and a positioning means configured to securing relative position between the scintillator and the frontend electronics. The PET detector module may further comprise a temperature control system, such as an air-cooling system or a heat exchange plate. The present disclosure also relates to a heat exchange plate, which comprises a fluidic passage for containing a flow of a heat exchange media. The heat exchange plate is suitable for use in the magnetic field environment of a MRI system.

A read network topology for a matrix output device with a number of outputs determined by cross-joining m rows and n columns comprises a basic filtering block replicated for all the outputs and separately assigned to each of the outputs; each filtering block contains two filtering circuits that have a common input connection to the assigned matrix output and that provide two separate symmetrical and filtered outputs; all the row outputs (i) from the same row i but from different columns are interconnected to an input of an amplifier linked to row i, and all the column outputs (j) from the same column j but from different rows are connected together to an input of an amplifier linked to column j, the complete topology appearing when i and j are expanded in the respective intervals thereof.

One embodiment provides a gamma camera system, including: a stand, a rotatable gantry supported by the stand, and a transformable gamma camera connected by mechanical supports to the rotatable gantry and comprising groups of tiled arrays of gamma detectors and a collimator for each group of tiled arrays of gamma detectors; the transformable gamma camera being configured to subdivide into a plurality of subdivided gamma cameras, each of the subdivided gamma cameras having at least one of the groups of tiled arrays of gamma detectors and corresponding collimator, wherein the subdivision into a plurality of subdivided gamma cameras facilitates contouring with a region of interest for a spatial resolution. Other embodiments are described and claimed.

A biocompatible column for concurrent micro-positron emission tomography (micro-PET) or micro-single photon emission computed tomography (micro-SPECT) of at least two cell cultures is provided, the column having an inlet, an axially oriented perfusion chamber and an outlet, wherein the perfusion chamber includes a porous solid phase with sponges having biopolymer (such as silk, silk fibroin, collagen, gelatin, agarose, alginate, polylactic acid, agar, or methyl-cellulose), an aqueous liquid phase, a first cell culture and a second cell culture, wherein the first cell culture and the second cell culture are in contact with the solid phase and wherein the first cell culture is separated from the second cell culture by the solid phase. Also provided is a method and a kit for concurrent micro-PET or micro-SPECT of at least two cell cultures.

A radiation detection device (300) is used in a nuclear medicine diagnosis apparatus, and includes a plurality of scintillators (44), a semiconductor light-receiving device (SiPM), a position detection circuit (214), and a timing detection circuit (216). Each of the scintillators converts a gamma ray emitted from a subject (15) into fluorescence. The semiconductor light-receiving device is provided corresponding to each of the scintillators and converts the fluorescence converted by a corresponding one of the scintillators into an electrical signal. The position detection circuit specifies a gamma ray detection position in the scintillators based on the electrical signal from the semiconductor light-receiving device. The timing detection circuit is connected to an anode of the semiconductor light-receiving device, and specifies time information corresponding to a time of occurrence of an event in which the gamma ray is detected.