The X-ray phase imaging apparatus includes a position switching mechanism for switching a relative position of one or more gratings between a retreated position which is an outside of a detection range on a detection surface of an image signal detector and a detection positon which is an inside of the detection range on the detection surface of the image signal detector and a focal diameter changing unit configured to change a focal diameter of the X-ray source in conjunction with switching of the relative position of the one or more gratings.

For calibration of internal dose in nuclear imaging, the dose model used for estimating internal dose in a patient is calibrated. One or more values of the dose model (e.g., a physics simulation, dose kernels, or a transport model) are set based on measured dose. The dose may be measured relative to specific tissues and/or isotopes, providing for tracer and tissue specific calibration. For example, dose from the tracer to be injected into the patient is estimated from emissions as well as measured by a dosimeter in a tissue mimicking tissue mimicking object. These doses are used to calibrate the dose model, which calibrated dose model is then used to determine internal dose for the patient.

A gamma camera device includes a collimator with pinholes which surrounds an object space for receiving an object, a detector surface for detecting gamma radiation emitted by the object and passing through pinholes of the collimator, and a controller for processing the detector signals into an image of the object. The collimator and the object space have a common longitudinal axis, wherein the collimator includes a plurality of groups each of multiple pinholes with a central line. In each group, the pinholes lie in a plane perpendicular to the longitudinal axis, wherein the pinholes of the groups together see a focus volume, which focus volume has a geometric center. Within each group, on a rotation around said longitudinal axis, the respective central line of each of said pinholes becomes congruent with the central line of each of the other pinholes of the group.

A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte, and identify patient administration factors that correlate with improper administration over a set of patients so as to identify administration risk factors to improve administration of radioactive analyte. In some cases, the system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

The invention relates to a combined imaging detector for detection of gamma and x-ray quanta comprising an x-ray detector (31) for generating x-ray detection signals in response to detected x-ray quanta and a gamma detector (32) for generating gamma detection signals in response to detected gamma quanta. The x-ray detector (31) and the gamma detector (32) are arranged in a stacked configuration along a radiation-receiving direction (33). The gamma detector (32) comprises a gamma collimator plate (320) comprising a plurality of pinholes (321), and a gamma conversion layer (322, 324) for converting detected gamma quanta into gamma detection signals.

A patient imaging system for creating visual representations for analysis includes an imaging source and a patient support disposed proximate the imaging source configured to receive and support the patient. An imaging device is disposed adjacent to the patient support and incorporates at least one detector, one or more slats cooperating with the at least one detector and a collimator disposed between the one or more slats and patient support having a plurality of links adjustably positionable on the collimator. The plurality of links receive and support imaging plates that may be adjusted to provide a variety of image settings such that the imaging device and imaging source define a pre-determined imaging volume in an imaging region for the patient positioned in the imaging system.

A method and apparatus are provided for positron emission imaging to calibrate timing of a pixelated gamma detector using multi-channel events. The apparatus can include processing circuitry configured to obtain calibration data representing a time and a position at which gamma rays are detected at a plurality of detector elements, and determine which gamma-ray detections of the calibration data correspond to multi-channel detections in which energy of a respective gamma ray is shared and detected by two or more of the plurality of detector elements. Additionally, the processing circuitry can be configured to determine a timing calibration of the plurality of detector elements by optimizing an objective representing agreement between time data of the multi-channel detections in the calibration data and the timing calibration.

A method for determining a correction profile of an imaging device may include obtaining first data relating to the imaging device; comparing the first data and a first condition; obtaining, based on the comparison, a first correction profile relating to the imaging device; and calibrating, based on the first correction profile, the imaging device.

A method for calibrating a nuclear medicine tomography detector module using principal component analysis is based on the idea that calibration beam data lies on a one-dimensional path within the higher dimensional dataspace of output data. The module includes a weighted multiplexing circuit that generates a small number of multiplexed signals for each photon event. Calibration data for the module is generated and analyzed using several iterations of principal component analyses, to filter scattering events, noise, and other spurious signals. The direction of depth-of-interaction information has been found in the high-dimensional dataspace to be indicated by the primary principal component of the calibration data. The primary principal components, principal components from filtered datasets, intermediate thresholds, and DOI or inner product values are recorded for calibrating the module.

The disclosure relates to a system and method for reconstructing a PET image. The method may include: obtaining PET data relating to an object collected by a plurality of detector units; determining functional status of the plurality of detector units; generating reconstruction data based on the functional status of the respective detector units and the PET data; and reconstructing a PET image based on the reconstruction data.