Provided are methods and compositions relating to a dental composition more specifically to prepare the damaged dentin of the tooth prior to repair. The dental compositions include a bioactive glass and a non-aqueous solvent comprising an alcohol, anti-inflammatory and anti-pain reliever.

A dental glass powder includes 15 to 40% by mass of zinc oxide (ZnO), 20 to 55% by mass of silicon oxide (SiO.sub.2), 6 to 20% by mass of aluminum oxide (Al.sub.2O.sub.3), 1 to 13% by mass of calcium oxide (CaO), and 1 to 19% by mass of fluorine (F).

A dental glass powder includes 15 to 40% by mass of zinc oxide (ZnO), 20 to 55% by mass of silicon oxide (SiO.sub.2), 6 to 20% by mass of aluminum oxide (Al.sub.2O.sub.3), 1 to 13% by mass of calcium oxide (CaO), and 1 to 19% by mass of fluorine (F).

A three-dimensional printing system including a feed source of uncured filled resin material, a print head configured to apply discrete layers of a composition including upconversion phosphors, and a radiation source configured to irradiate layers of uncured filled resin material and deposited layers of the composition is provided. A method of three dimensionally printing a dental article is also provided.

A three-dimensional printing system including a feed source of uncured filled resin material, a print head configured to apply discrete layers of a composition including upconversion phosphors, and a radiation source configured to irradiate layers of uncured filled resin material and deposited layers of the composition is provided. A method of three dimensionally printing a dental article is also provided.

A method of forming a stabilized calcium phosphate moiety for use in dental or biomedical applications includes providing a solution or dispersion including a calcium salt and reacting an organic phosphate having a polymerizable methacrylate or vinyl group with the solution or dispersion in order to form the calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group, which may be the same group. A polymerizable composite system having a stabilized calcium phosphate formed according to the method is also provided.

A method of forming a stabilized calcium phosphate moiety for use in dental or biomedical applications includes providing a solution or dispersion including a calcium salt and reacting an organic phosphate having a polymerizable methacrylate or vinyl group with the solution or dispersion in order to form the calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group, which may be the same group. A polymerizable composite system having a stabilized calcium phosphate formed according to the method is also provided.

The invention relates to a process for the preparation of a citrate-coated amorphous calcium phosphate nanoparticle which comprises the following steps: 1) providing a first solution of a salt of calcium and a citrate salt wherein the molar ratio of citrate ion to calcium ion is in the range from 1 to 2 thus obtaining a clear first solution; 2) providing a second solution of a salt capable to give phosphate anion and a carbonate salt; 3) mixing together the first and the second solution at a pH in the range from 8 to 11; 4) precipitating the nanoparticle; and 5) drying the nanoparticle obtained from step 4). Preferably and advantageously the invention provides for the addition of a fluoride compound in step 2) for obtaining a fluorine-doped citrate-coated calcium phosphate nanoparticle or a nanoparticle agglomerate. The nanoparticle/nanoparticle agglomerate of the invention has a peculiar superficial area and a diameter that allow to use it as a biomaterial for dentistry application.

A pre-mixed strontium silicate-based biological hydraulic cement paste composition and preparation method and use thereof are disclosed. The pre-mixed strontium silicate-based biological hydraulic cement paste of the disclosure uses strontium silicate as the main phase and at least one non-aqueous solvent that is miscible with water, and preferably, it may further include at least one calcium phosphate compound and at least one radiopaque material, to prepare a biological hydraulic cement paste with excellent injectability. The material remains as a fluid under a sealed condition, and hydrates, solidifies and hardens when it is placed in a physiological environment and contacts with a physiological body fluid. The strontium silicate-based material having excellent biocompatibility and biological activity is used to prepare a pre-mixed strontium silicate-based cement paste, which can be used for medical and dental applications including fields of pulp capping, root canal therapy, dental restorations and the like.

A pre-mixed strontium silicate-based biological hydraulic cement paste composition and preparation method and use thereof are disclosed. The pre-mixed strontium silicate-based biological hydraulic cement paste of the disclosure uses strontium silicate as the main phase and at least one non-aqueous solvent that is miscible with water, and preferably, it may further include at least one calcium phosphate compound and at least one radiopaque material, to prepare a biological hydraulic cement paste with excellent injectability. The material remains as a fluid under a sealed condition, and hydrates, solidifies and hardens when it is placed in a physiological environment and contacts with a physiological body fluid. The strontium silicate-based material having excellent biocompatibility and biological activity is used to prepare a pre-mixed strontium silicate-based cement paste, which can be used for medical and dental applications including fields of pulp capping, root canal therapy, dental restorations and the like.