A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present invention discloses a root canal dental paste that has include a first portion made from at least one antibiotic compound and partially set calcium based cement which forms a matrix to at least partially encapsulate the antibiotic compound. The first portion is then ground and combined with a second portion being a non-setting material and an antibiotic to form a paste.

The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprisingSi oxide calculated as SiO2 from 55 to 80 wt.-%, Li oxide calculated as Li2O from 7 to 16 wt.-%, Al oxide calculated as Al2O3 from 1 to 5 wt.-%, andP oxide calculated as P2O5 from 1 to 5 wt.-%, wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600 C. The present invention is also directed to a kit of parts comprising a porous 3-dim article having the shape of a dental milling block and a respective instruction of use.

The present invention relates to: composition for differentiating non-dental mesenchymal stem cells into odontoblasts comprising CPNE7 protein or gene; method for differentiating in vitro non-dental mesenchymal stem cells using the same; and also use thereof.

The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprising Si oxide calculated as SiO2 from 55 to 80 wt.-%, Li oxide calculated as Li2O from 7 to 16 wt.-%, Al oxide calculated as Al2O3 from 1 to 5 wt.-%, and P oxide calculated as P2O5 from 1 to 5 wt.-%, wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600 C.

The present invention is also directed to a kit of parts comprising a porous 3-dim article having the shape of a dental milling block and a respective instruction of use.

Disclosed are a composite resin denture porcelain block, a preparation method thereof and a composite resin denture. The composite resin denture porcelain block includes 0.1% to 15% of carbamate dimethacrylate, 0.1% to 10% of bisphenol A-di glycidyl methacrylate, 3% to 20% of triethylene glycol dimethacrylate, 35% to 85% of glass powder, 0.1% to 8% of ZrO.sub.2, 3% to 15% of SiO.sub.2, 0.1% to 40% of ZrO.sub.2SiO.sub.2 composite powder, 2% to 17% of diatomite, 0.01% to 3% of benzoyl peroxide, 0.01% to 3% of N,N dihydroxyethyl p-toluidine, 0.01% to 3% of 2,6 di-tert-butyl p-cresol, 0.001% to 0.2% of iron oxide red, 0.001% to 0.2% of iron oxide black, and 0.001% to 0.5% of iron oxide yellow. The composite resin denture porcelain block of the present application uses carbamate dimethacrylate, bisphenol A-di glycidyl methacrylate, and triethylene glycol dimethacrylate as the resin matrix.

Disclosed are a composite resin denture porcelain block, a preparation method thereof and a composite resin denture. The composite resin denture porcelain block includes 0.1% to 15% of carbamate dimethacrylate, 0.1% to 10% of bisphenol A-di glycidyl methacrylate, 3% to 20% of triethylene glycol dimethacrylate, 35% to 85% of glass powder, 0.1% to 8% of ZrO.sub.2, 3% to 15% of SiO.sub.2, 0.1% to 40% of ZrO.sub.2SiO.sub.2 composite powder, 2% to 17% of diatomite, 0.01% to 3% of benzoyl peroxide, 0.01% to 3% of N,N dihydroxyethyl p-toluidine, 0.01% to 3% of 2,6 di-tert-butyl p-cresol, 0.001% to 0.2% of iron oxide red, 0.001% to 0.2% of iron oxide black, and 0.001% to 0.5% of iron oxide yellow. The composite resin denture porcelain block of the present application uses carbamate dimethacrylate, bisphenol A-di glycidyl methacrylate, and triethylene glycol dimethacrylate as the resin matrix.

Crosslinked polymeric particles obtainable by copolymerization, in the presence of a chain transfer reagent, of at least one difunctional radically polymerizable monomer, optionally at least one monofunctional radically polymerizable monomer and at least one thiourea derivative according to the following Formula (I):

##STR00001## in which R is an (n+1)-valent, aromatic, aliphatic, linear or branched C.sub.1-C.sub.50 hydrocarbon radical, which can be interrupted by one or more, preferably 1 to 8, particularly preferably 1 to 6, ether, thioether, ester, amide or urethane groups; PG is a radically polymerizable (meth)acrylate, (meth)acrylamide or vinyl group and n is 1 or 2. In combination with a hydroperoxide, the crosslinked polymeric particles are suitable as redox initiator system for the free-radical polymerization of compositions comprising at least one radically polymerizable monomer. These compositions are particularly suitable as dental materials.

Crosslinked polymeric particles obtainable by copolymerization, in the presence of a chain transfer reagent, of at least one difunctional radically polymerizable monomer, optionally at least one monofunctional radically polymerizable monomer and at least one thiourea derivative according to the following Formula (I):

##STR00001## in which R is an (n+1)-valent, aromatic, aliphatic, linear or branched C.sub.1-C.sub.50 hydrocarbon radical, which can be interrupted by one or more, preferably 1 to 8, particularly preferably 1 to 6, ether, thioether, ester, amide or urethane groups; PG is a radically polymerizable (meth)acrylate, (meth)acrylamide or vinyl group and n is 1 or 2. In combination with a hydroperoxide, the crosslinked polymeric particles are suitable as redox initiator system for the free-radical polymerization of compositions comprising at least one radically polymerizable monomer. These compositions are particularly suitable as dental materials.