A metering device for a machine for making a liquid preparation includes a liquid reservoir for storing a fluid and for feeding, via an inlet line, at least one pump arranged to force the fluid to pass, in the liquid and/or vapour state, through at least one doser including at least one ingredient, in order to make the preparation, and to dispense the preparation to an outlet line. The metering device also includes means for continuously measuring the mass of the reservoir and of its contents, and control means interfaced with the continuous measurement means and arranged to monitor the total mass as a function of time, and to instantaneously calculate the mass of the preparation already dispensed, to adapt the duration of operation of the pump to ensure that the exact quantity of preparation required is dispensed, and/or to trigger the shutdown of the pump if it is found to be running dry.

A containment assembly for enclosing a medication container may comprise a first housing portion or interface portion having a proximal end and a distal end. The interface portion may include a housing wall which defines a channel spanning from the proximal end to the distal end. The channel may be open at the proximal and distal end. The containment assembly may further comprise only two pierceable septa configured to form a barrier to the channel. The containment assembly may further comprise a variable-volume housing portion having a variable volume chamber. The variable-volume portion chamber of the variable-volume housing portion may be in fluid communication with the distal end of the channel.

A pharmaceutical compounding system having automated micro-dosing capability and using exchangeable source containers containing respective drugs, the system comprising an automated capsule-filling machine configured for compounding: an interface configured for receiving of prescription information for particular patients; and a dispensing head containing a solid-form drug; wherein said drug can be dispensed from said dispensing head by said machine such that the drug's active pharmaceutical ingredient (API) alone can be accurately dosed; and wherein the dispensing head is part of a set of multiple dispensing heads configured for compounding with said system.

A method of making a pharmaceutical compounding system having automated micro-dosing capability, the method comprising identifying a technology that can facilitate controlled and automated dispensation of material, such that the dispensation does not necessitate augmentation of material by mass or volume to aid with measurement or manipulation in order to achieve a level of dispensing precision that can be medically acceptable for at least some drug substances; and adapting the technology for prescription-specific operability for producing customized drug products, the adapting comprising configuring the technology for production of pills in prescribed numbers with prescribed drugs at prescribed doses via distinct runs for respective patients.

A containment assembly for enclosing a medication container may comprise a first housing portion or interface portion having a proximal end and a distal end. The interface portion may include a housing wall which defines a channel spanning from the proximal end to the distal end. The channel may be open at the proximal and distal end. The containment assembly may further comprise at least one pierceable septum disposed at least at one of: on the proximal end of the channel and within the channel forming a barrier between the proximal end of the channel and distal end of the channel of the interface portion. The containment assembly may further comprise a variable-volume housing portion having a variable volume chamber. The variable-volume portion chamber of the variable-volume housing portion may be in fluid communication with the distal end of the channel.

Systems and methods for dispensing chemicals include an eductor having a diluent inlet, a chemical pickup port, a discharge port, and a venturi fluidly coupled between the diluent inlet and the discharge port. A diluent valve having an outlet is coupled to the diluent inlet. A chemical manifold includes a plurality of chemical inlets and a chemical outlet fluidly coupled to the chemical pickup port. A plurality of chemical valves are each coupled to one of the plurality of chemical inlets; and a controller is communicatively coupled to the diluent valve and the plurality of chemical valves and configured to operate the diluent valve and the chemical valves to dispense measured doses of individual chemicals through the chemical pickup port.

A liquid outpouring method and a liquid outpouring device are provided. The liquid outpouring method comprises: outpouring, at a constant volume, a preset liquid at first outpouring precision; performing static weighing on the liquid which is outpoured at the constant volume, and determining an actual liquid outpouring amount; calculating a remaining liquid outpouring amount according to the actual liquid outpouring amount and a target outpouring amount; and outpouring, at a constant volume, the remaining liquid outpouring amount at second outpouring precision, wherein the first outpouring precision is lower than the second outpouring precision, and an outpouring error of outpouring the liquid at the first outpouring precision is greater than an outpouring error of outpouring the liquid at the second outpouring precision.

A gravimetric blending system can include fluid storage reservoirs, a pivotable dispensing arm having dispensing nozzles, wherein each dispensing nozzle is configured to dispense a predetermined amount of fluid from each fluid storage reservoir a fluid container, and a scale configured to detect a weight applied to the scale. The gravimetric blending system may further include a controller configured to receive user inputs, identify a fluid contained within one of the fluid storage reservoirs that will contribute to the blend and the required weight of the fluid. The controller may be further configured to identify the expected change in weight to be detected by the scale, cause an amount of the fluid to be dispensed, detect the weight applied to the scale after the fluid has been dispensed, compare the detected weight to the expected change in weight, and determine if the expected weight of the fluid was dispensed.