A61K8/044

Self-assembled amino acid supramolecular polymer, preparation method therefor, and application thereof
11540993 · 2023-01-03 · ·

Disclosed are a novel self-assembled amino acid supramolecular polymer, a preparation method therefor, and an application thereof. The self-assembled supramolecular polymer is N-lauroyl-L-alanyl-L-alanine or a salt thereof, and the salt thereof comprises sodium N-lauroyl-L-alanyl-L-alaninate and potassium N-lauroyl-L-alanyl-L-alaninate. The disclosed polymer is more effective at inhibiting bacteria and removing pesticides, and can be widely applied to the daily chemical, agricultural, and pharmaceutical industries. Further disclosed are three methods for preparing the compound. The methods produce products in high yields and are suitable for industrial production.

ARTICLES OF MANUFACTURE COMPRISING NANOCELLULOSE ELEMENTS

The present invention provides formulations comprising a suspension of nanocellulose (NC) elements and a drying/dispersal additive selected from the group consisting of temperature-responsive polymers, small molecule additives in volatile systems, and blocking agents and methods of preparing such formulations, and further provides NC-containing materials, composite materials and useful articles of manufacture made therefrom.

Lyophilized formulation of stem cell-derived exosomes and anti-inflammatory composition including the same as active ingredient
11529306 · 2022-12-20 · ·

The lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to stabilize stem cell-derived exosomes and exhibit excellent anti-inflammatory effects, and particularly, exhibit remarkable anti-inflammatory effects as compared with not-lyophilized stem cell-derived exosomes isolated and purified from conditioned media of stem cells. Therefore, the lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to effectively prevent, suppress, alleviate, ameliorate or treat inflammatory response or inflammatory diseases.

COMPOSITION FOR THE MAKING OF AN EMULSIFIABLE TRIPHASIC FORMULATION, AND KIT FOR THE USE OF SUCH COMPOSITION
20220395437 · 2022-12-15 ·

The invention relates to a composition for the making of an emulsifiable triphasic formulation, which consists of a liquid biphasic composition and a powder solid phase, wherein said liquid biphasic composition consists of a hydrophilic phase and a lipophilic phase. The triphasic emulsifiable composition obtained from the combination of the biphasic liquid composition and the solid powder phase by a kit of the invention is particularly suitable for the use in the clinical-dermatological and/or cosmetological fields.

Compositions comprising solvent, a monoalcohol and glycerin
11517774 · 2022-12-06 · ·

The present invention relates to compositions for removing nail polish that include a C2-C3 monoalcohol, at least about 15% glycerin, and at least about 20% by weight of a C2-C4 alkyl acetate, and combinations thereof. The compositions include less water than glycerin. Methods of using these compositions to remove nail polish and moisturize the hands are also provided.

Kit for delivery of an active compound into the skin
11510883 · 2022-11-29 · ·

A kit for enabling delivery of an active compound to the skin for penetration into the skin, a delivery device for delivering an active compound, and a method of delivery of an active compound are provided. An active compound delivery kit for enabling delivery of an active compound into the skin of a subject includes an arrangement for providing a pathway into a biological barrier of a subject in an application zone, an active compound provided in dry form, and a delivery device for delivery of dissolved active compound to the application zone. Provision of a pathway into the biological barrier, preferably skin, is provided and the active compound applied in optimum form within a short time frame after forming the pathway ensuring treatment of the desired skin cells is optimised.

ULTRA LONG-LASTING MAKE-UP FOUNDATION

The present invention relates to a cosmetic make-up composition for the skin in the form of a water-in-oil (W/O) emulsion comprising in a physiological acceptable medium at least: a) an aqueous polyurethane dispersion, b) a hydrophobic film-forming polymer, c) one or more volatile hydrocarbon oils, preferably in an amount of at least 10 wt % relative to the total weight of the composition, d) one or more absorbent fillers having an oil uptake greater than or equal to 30 ml/100 g and e) pigments.

TOPICAL PHARMACEUTICAL FORMULATIONS CONTAINING A LOW CONCENTRATION OF BENZOYL PEROXIDE IN SUSPENSION IN WATER AND A WATER-MISCIBLE ORGANIC SOLVENT
20230047106 · 2023-02-16 ·

An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

OIL-IN-OIL EMULSIFIED COSMETIC

The purpose of the present invention is to provide an oil-in-oil emulsified cosmetic having exceptional transfer resistance after application, luster, excellent spread during application, and especially exceptional cosmetic durability. The present invention pertains to an oil-in-oil emulsified cosmetic characterized by containing (a) 5-80 mass % of a nonvolatile hydrocarbon oil and/or nonvolatile ester oil, (b) 1-70 mass % of a nonvolatile silicone oil, and (c) 2-12 mass % of a spherical powder having an average particle size of 1-10 μm, the oil-in-oil emulsified cosmetic moreover being characterized in that the (a) nonvolatile hydrocarbon oil and/or nonvolatile ester oil and the (b) nonvolatile silicone oil separate when mixed at 25° C. The blend ratio (mass ratio) of the (a) nonvolatile hydrocarbon oil and/or nonvolatile ester oil and the (b) nonvolatile silicone oil is preferably (a)/[(a)+(b)]=0.4-0.8.

Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent

An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.