Provided are a multilayered cationic liposome for enhancing skin absorption, a cosmetic composition including the same, and a method of preparing the same.

Provided are a multilayered cationic liposome for enhancing skin absorption, a cosmetic composition including the same, and a method of preparing the same.

The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.

Compositions and methods for cleansing the eyelid and treating an ocular condition are disclosed herein. A method for treating an ocular condition involves cleansing an eyelid with a first ophthalmic composition, wherein the first ophthalmic composition consists essentially of water, PEG-80 sorbitan laurate, methyl gluceth-20, PEG-120 methyl glucose dioleate, salicyloyl phytosphingosine, decyl glucoside, 1,2 hexanediol, caprylyl glycol, disodium cocoamphodiacetate, panthenol, polyaminopropyl biguanide, sodium chloride, potassium chloride and calcium chloride followed by applying a therapeutically effective amount of a second ophthalmic composition to a margin of the eyelid, wherein the second ophthalmic composition consists essentially of water and hypochlorous acid.

Compositions and methods for cleansing the eyelid and treating an ocular condition are disclosed herein. A method for treating an ocular condition involves cleansing an eyelid with a first ophthalmic composition, wherein the first ophthalmic composition consists essentially of water, PEG-80 sorbitan laurate, methyl gluceth-20, PEG-120 methyl glucose dioleate, salicyloyl phytosphingosine, decyl glucoside, 1,2 hexanediol, caprylyl glycol, disodium cocoamphodiacetate, panthenol, polyaminopropyl biguanide, sodium chloride, potassium chloride and calcium chloride followed by applying a therapeutically effective amount of a second ophthalmic composition to a margin of the eyelid, wherein the second ophthalmic composition consists essentially of water and hypochlorous acid.

There is provided a method for stably dispersing a naturally occurring free ceramide (in particular, a naturally occurring human-type free ceramide) containing a long-chain fatty acid in the ceramide skeleton in an aqueous phase. More specifically, provided is a ceramide dispersion composition comprising a naturally occurring free ceramide, a nonionic surfactant, a phospholipid, and a C.sub.2-6 diol, the mass ratio of the naturally occurring free ceramide to the diol being 1:3 to 25, the naturally occurring free ceramide comprising a free ceramide that contains a fatty acid having 20 or more carbon atoms in the ceramide skeleton thereof.

There is provided a method for stably dispersing a naturally occurring free ceramide (in particular, a naturally occurring human-type free ceramide) containing a long-chain fatty acid in the ceramide skeleton in an aqueous phase. More specifically, provided is a ceramide dispersion composition comprising a naturally occurring free ceramide, a nonionic surfactant, a phospholipid, and a C.sub.2-6 diol, the mass ratio of the naturally occurring free ceramide to the diol being 1:3 to 25, the naturally occurring free ceramide comprising a free ceramide that contains a fatty acid having 20 or more carbon atoms in the ceramide skeleton thereof.

The composition of external application to the skin according to the present invention may specifically control the relative amount between long-chain amides and sterols and the relative amount between lipid components and an emulsifier in the emulsion having a multi-layered lamella structure, the emulsion comprising a relatively larger content of dermatologically useful hydrophobic material in a formulation. Thus, the formulation having significantly high stability and excellent characteristics can be obtained in spite of the high content in the lipid components and the emulsifier.

The composition of external application to the skin according to the present invention may specifically control the relative amount between long-chain amides and sterols and the relative amount between lipid components and an emulsifier in the emulsion having a multi-layered lamella structure, the emulsion comprising a relatively larger content of dermatologically useful hydrophobic material in a formulation. Thus, the formulation having significantly high stability and excellent characteristics can be obtained in spite of the high content in the lipid components and the emulsifier.

The present disclosure relates to a cosmetic composition of dispersion formulation including: a aqueous phase as an external phase; and an oil phase consisting of spherical particles dispersed in the aqueous phase, wherein the spherical particles including an alcohol having 22 or less carbon atoms and a sucrose-based surfactant, wherein the cosmetic composition has excellent formulation stability by including the spherical particles, and causes no irritation when applied to the skin.