The invention concerns a composition, advantageously cosmetic, comprising: at least one basic amino acid selected from the group constituted by arginine, lysine, histidine, ornithine, hydroxyproline and one of their salts; and at least one glycosylceramide,
and its use for preventing and/or treating atopic dermatitis.

Provided are a novel pseudoceramide compound and a skin external composition comprising the same. The skin external composition comprising a pseudoceramide compound or a pharmaceutically acceptable salt or solvate thereof according to the present invention as an active ingredient has an excellent effect of improving a skin barrier function, thereby exhibiting an effect of improving inflammatory skin diseases, and also is excellent in the function of improving the skin barrier and the effect of enhancing skin moisture.

The present invention provides a water-in-oil emulsion composition having a high water occlusive of a coating film and having good skin protective feeling and glossiness. The water-in-oil emulsion composition is provided containing the following components (A), (B), (C), (D) and (E): (A) 1% by mass or more and 15% by mass or less of a lipophilic surfactant having an HLB of 2-6; (B) 0.15% by mass or more and 8% by mass or less of a dextrin fatty acid ester having 8-22 carbon atoms in the fatty acid moiety; (C) 1% by mass or more and 20% by mass or less of one or more oily components selected from a dimer acid ester, a fatty acid cholesterol ester having 16-22 carbon atoms, a fatty acid phytosterol ester having 16-22 carbon atoms, and an N-acyl amino acid ester; (D) a hydrocarbon oil that is liquid at 25° C.; and (E) water.

The present invention provides a water-in-oil emulsion composition having a high water occlusive of a coating film and having good skin protective feeling and glossiness. The water-in-oil emulsion composition is provided containing the following components (A), (B), (C), (D) and (E): (A) 1% by mass or more and 15% by mass or less of a lipophilic surfactant having an HLB of 2-6; (B) 0.15% by mass or more and 8% by mass or less of a dextrin fatty acid ester having 8-22 carbon atoms in the fatty acid moiety; (C) 1% by mass or more and 20% by mass or less of one or more oily components selected from a dimer acid ester, a fatty acid cholesterol ester having 16-22 carbon atoms, a fatty acid phytosterol ester having 16-22 carbon atoms, and an N-acyl amino acid ester; (D) a hydrocarbon oil that is liquid at 25° C.; and (E) water.

The present invention relates to a method for purification of liquid compositions containing at least one sphingolipid and the use of a specific clay mineral for the purification of such liquid compositions.

The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.

The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.

A topical skin composition containing a sphingolipid having a branched chain fatty acid as an active ingredient and its uses are disclosed. The topical composition is useful in preventing adsorption of fine dust, improving a skin barrier function, and exhibiting an excellent skin moisture effect. A preparation method for the topical composition is also disclosed.

A topical skin composition containing a sphingolipid having a branched chain fatty acid as an active ingredient and its uses are disclosed. The topical composition is useful in preventing adsorption of fine dust, improving a skin barrier function, and exhibiting an excellent skin moisture effect. A preparation method for the topical composition is also disclosed.

According to the present invention there is provided a cosmetic composition comprising: (i) a polyphenolic antioxidant agent; and (ii) a sphingosine compound.