The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.

The present invention is directed to a personal care composition comprising azoxystrobin having a minimum inhibitory concentration (MIC) of less than 1.0 ppm against Malassezia and at least a 4 times or greater MIC against Malassezia compared to strobilurins selected from the group consisting of pyraclostrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, trifloxystrobin, or orysastrobin.

Personal care compositions in the form of a stable oil-in-water emulsion comprises: (i) a continuous aqueous phase N comprising water; (ii) a discontinuous phase comprising foam forming component (s), tans-1-chloro-3, 3, 3-trifluoropropene (1233zd (E)) and trans-1-3, 3, 3-tetrafluoropropene (1234ze (E)), wherein said 1233zd (E) and said 1234ze (E) together comprise from about 40% to about 60% by weight of said personal car composition and are present in a trans1233zd:trans1234ze weight ratio of from about 8:1 to about 8:1; (iii) an emulsifier having an HLB value of from about 7 to about 18 and which may be present in the continuous and/or discontinuous phase; and (iv) one or more active ingredients which maybe present in the continuous and/or discontinuous phase. A method of treating human skin, hair and/or mucous membranes comprises providing the personal care composition.

Personal care compositions in the form of a stable oil-in-water emulsion comprises: (i) a continuous aqueous phase N comprising water; (ii) a discontinuous phase comprising foam forming component (s), tans-1-chloro-3, 3, 3-trifluoropropene (1233zd (E)) and trans-1-3, 3, 3-tetrafluoropropene (1234ze (E)), wherein said 1233zd (E) and said 1234ze (E) together comprise from about 40% to about 60% by weight of said personal car composition and are present in a trans1233zd:trans1234ze weight ratio of from about 8:1 to about 8:1; (iii) an emulsifier having an HLB value of from about 7 to about 18 and which may be present in the continuous and/or discontinuous phase; and (iv) one or more active ingredients which maybe present in the continuous and/or discontinuous phase. A method of treating human skin, hair and/or mucous membranes comprises providing the personal care composition.

The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and/or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, Tinea versicolor, Pityriasis versicolor, Tinea circinata, Tinea pedis, Tinea unguium, Tinea manus, Tinea cruris, Tinea corporis, Tinea faciei, Tinea capitis, and/or Tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

Disclosed are personal care formulations, personal care methods and personal care devices that comprise or use a gel, lotion, cream or the like comprising (a) one or more active ingredients for providing a beneficial effect to the skin and/or hair and/or mucous membranes of a human and (b) from about 1 percent by weight to about 50 percent by weight of foam forming component(s) comprising trans-1-chloro-3,3,3-trifluoropropene (1233zd(E).

Disclosed are personal care formulations, personal care methods and personal care devices that comprise or use a gel, lotion, cream or the like comprising (a) one or more active ingredients for providing a beneficial effect to the skin and/or hair and/or mucous membranes of a human and (b) from about 1 percent by weight to about 50 percent by weight of foam forming component(s) comprising trans-1-chloro-3,3,3-trifluoropropene (1233zd(E).

The present invention is directed to a foaming composition comprising from about 5% to about 13% total surfactant of one or more anionic surfactants; from 0.1% to about 2% of a surfactant soluble antidandruff active; from about 3% to about 15% of a blowing agent, wherein the foaming composition is at a pH of about 3.5 to 6.5.

Abstract: The present disclosure relates to a composition for use in the hair follicle modulation comprising a bioactive agent a thickener agent; a preservative; and a denaturing alcohol. The present disclosure also comprises a pharmaceutical composition for use in the prevention, therapy or treatment of abnormal defective production of melanin, comprising a bioactive agent selected from dipyridamole, dipyridamole salt, rivastigmine, rivastigmine salt, paroxetine, paroxetine salt, or mixtures thereof. The use of said bioactive agent as a hair modulator is also encompassed.

The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.