Patent classifications
A61K8/90
HYDROQUINONE STABILIZING COMPOSITION
Provided in the present disclosure is a composition comprising hydroquinone or a derivative thereof as an active ingredient, and characterized in that the hydroquinone or the derivative thereof is stabilized by means of poloxamer. The composition of the present disclosure increases the soluble concentration of the hydroquinone or the derivative thereof, can have high melt stability without precipitation even at high concentration in water, can enhance storage stability by preventing oxidation reaction to external stimulations such as heat, oxygen and light, can prevent discoloration, and thus has reduced toxicity induced by an oxidation product of the hydroquinone and can reduce inflammatory response. Also, the composition of the present disclosure can enhance whitening efficacy by enhancing the skin permeability of the hydroquinone or the derivative thereof by means of micelles, and thus is useful for a whitening activity having hydroquinone or a derivative thereof as an active ingredient.
THICKENER FOR NON-AQUEOUS COMPOSITIONS
A thickener for a non-aqueous system includes a water-soluble polymer and a counterpart that ionically and/or electrostatically interacts with the water-soluble polymer.
Oral Care Compositions
Described herein are oral care compositions comprising: from about 35 wt. % to about 85 wt. % of an anhydrous solvent system (e.g., 35 wt. % to about 75 wt. %); from about 0.02 wt. % to about 30 wt. % of a peroxide solution comprising: from about 0.01 wt. % to about 15 wt. % of hydrogen peroxide, and from about 0.01 wt. % to about 15 wt. % of water; from about 1 wt. % to about 20 wt. % of a thickening system; wherein the oral care composition has a total water content of less than about 30 wt. %; and wherein all weight percentages are based on the total weight of the oral care composition. Methods of making and using these compositions are also described herein.
Oral Care Compositions
Described herein are oral care compositions comprising: from about 35 wt. % to about 85 wt. % of an anhydrous solvent system (e.g., 35 wt. % to about 75 wt. %); from about 0.02 wt. % to about 30 wt. % of a peroxide solution comprising: from about 0.01 wt. % to about 15 wt. % of hydrogen peroxide, and from about 0.01 wt. % to about 15 wt. % of water; from about 1 wt. % to about 20 wt. % of a thickening system; wherein the oral care composition has a total water content of less than about 30 wt. %; and wherein all weight percentages are based on the total weight of the oral care composition. Methods of making and using these compositions are also described herein.
Hyperbranched polyglycerol-coated particles and methods of making and using thereof
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
Hyperbranched polyglycerol-coated particles and methods of making and using thereof
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
Peroxymonosulfate Oral Whitening Compositions
The present disclosure provides tooth whitening oral care compositions comprising potassium peroxymonosulfate having improved stability, and methods of using the same.
Skin perfecting cosmetic compositions and methods of use
Skin tightening compositions for application to the skin for providing an instantaneous and dramatic improvement to the appearance of skin. The skin tightening compositions typically include about 5 to about 45 wt. % or more of one or more hydrophobic film-forming polymers comprising acrylates/stearyl methacrylate copolymer; about 0.5 to about 20 wt. % of a mineral thickening agent; about 1 to about 15 wt. % of a silicone elastomer; and about 30 to about 85 wt. % of a volatile hydrocarbon oil, wherein all percentages by weight are based on the total weight of the skin tightening composition. Additionally, the skin tightening composition may have a weight ratio of the total amount of hydrophobic film-forming polymers to the total amount of mineral thickening agent is 1:1 to 10:1 and a weight ratio of the total amount of silicone elastomer to the total amount of mineral thickening agent is 1:2 to 8:1.
HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.