An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device.

An intrauterine contraceptive system may include a contraceptive intrauterine device, a retrieval thread permanently attached to the intrauterine device and an insertion device for inserting the intrauterine device into a uterus. The system may also include a release thread releasably coupled with the intrauterine device. The intrauterine device may be deployable out of a distal end of the insertion device and may be configured to change from a delivery configuration when housed in the insertion device to a deployed configuration when deployed in a uterus. The retrieval thread and the optional release thread may be at least partially housed within the insertion device during insertion of the intrauterine device into the uterus. The release thread may extend from the intrauterine device through the insertion device to an attachment point at or near a proximal end of the insertion device.

Ammonia oxidizing microorganism preparations for delivery to the urogenital system, kits including ammonia oxidizing preparations for delivery to the urogenital system, and devices for administering ammonia oxidizing preparations to the urogenital system are provided. Methods of introducing ammonia oxidizing microorganisms to the urogenital system are provided. Methods of treating disorders, including urogenital disorders and inflammatory disorders, with ammonia oxidizing microorganism preparations are provided.

A method and intravaginal drug delivery device for reducing size of a uterine fibroid in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to uterine fibroid, wherein said amount is able to significantly reduce the size of the uterine fibroid, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.

Devices and methods for removing an intravaginal drug delivery ring are shown and described. In one embodiment, the device is an integral one-piece moisture impermeable structure that includes a closed end finger cot and a substantially rigid hook. Typically, the closed end finger cot includes a finger opening, a compression band, and an expandable sleeve. In some examples, the distal end of the hook is aligned substantially parallel to an axis of the finger cot to properly position the user's finger with the intravaginal drug delivery ring in the vaginal canal. The result is devices and methods to improve removal of intravaginal drug delivery rings and similar contraception prevention units.

A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.

A flexible implantable contraceptive disc device can be inserted inside the female body. The circular device can be bent and inserted into a laparoscopy tube, which allows it to be delivered to the appropriate location inside a female subject. The disc has three layers, a central core silicon reservoir containing the active ingredient, such as a contraceptive, which is sandwiched and encased by upper and lower porous silicon casings. The casings are porous to the contraceptive, allowing controlled release over a prolonged period of time. The lower casing has a series of micro-hooks around the circumference, allowing the disc device to be attached to a desired tissue by rotating the disc such that the hooks engage with the tissue. Such a device is easier to insert, and to remove, than the rod-like rigid plastic T-shape IUDs which are considerably larger and more expensive to manufacture.

An intravaginal drug delivery device comprising: a drug delivery device, and a therapeutically effective amount of a single active agent that is therapeutically effective for the treatment of endometriosis, wherein the drug delivery device delivers the single active agent directly to endometrial implants in women diagnosed with endometriosis, wherein the single active agent is selected from the group consisting of mifepristone and metabolites thereof.

A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.

Devices and methods for removing an intravaginal drug delivery ring are shown and described. In one embodiment, the device is an integral one-piece moisture impermeable structure that includes a closed end finger cot and a substantially rigid hook. Typically, the closed end finger cot includes a finger opening, a compression band, and an expandable sleeve. In some examples, the distal end of the hook is aligned substantially parallel to an axis of the finger cot to properly position the user's finger with the intravaginal drug delivery ring in the vaginal canal. The result is devices and methods to improve removal of intravaginal drug delivery rings and similar contraception prevention units.