The invention provides a dosage form and a bolus configured for administration to an animal, wherein said dosage form and said bolus is configured to release a methane inhibitor to the animal over a period of time. Preferably the methane inhibitor is a haloform. Also provided is the use of the bolus of the invention to reduce methane production in a ruminant animal. Also provided is the method of manufacturing a bolus of the invention.

The invention provides a delayed release dosage form and a bolus configured for administration to an animal, wherein said dosage form and said bolus is configured to release a hydrophobic substance to the animal over a period of time. Preferably the hydrophobic substance is a haloform. Also provided is the use of the delayed release dosage form or bolus of the invention to reduce methane production in a ruminant animal. Also provided is the method of manufacturing a bolus of the invention.

The present invention discloses 2-aminoindane Formulas I and II and their pharmaceutically acceptable salts, compositions and methods of use to modulate central nervous system activity, and to treat central nervous system disorders, such as post-traumatic stress, depression, anxiety, and adjustment disorders. In certain embodiments, the compounds of the present invention can be used for entactogenic therapy in counseling sessions, as needed periodically or consistently as necessary or desired.

A slow-release bolus product administered to the reticulo-rumen of a ruminant animal like a cow containing dried live active yeast particles, vitamins, and optional minerals for enhancing the health, nutrition, and feed intake of the animal prior to a lactation cycle post calving and to improve commercial milk production, or for enhancing the health, nutrition, and feed intake of a ruminant animal after a triggering stress event.

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.

An intra-ruminal device includes a body substantially impervious to rumen fluid, the body including a barrel, at least one outlet, at least one matrix including at least one active ingredient and at least one clay mineral, a compression arrangement and at least one variable geometry device dependent from the body. Use of the intra-ruminal device and a method of treating a ruminant animal by administering the intra-ruminal device to the animal are also disclosed.