The present invention provides a method for manufacturing a water-in-oil-in-water multiple emulsion, comprising: (a) mixing an active component with an internal aqueous phase to form a homogenized mixture; (b) mixing the homogenized mixture with an oleaginous phase to form a water-in-oil emulsion; and (c) mixing the water-in-oil emulsion with an external aqueous phase to form the water-in-oil-in-water multiple emulsion, wherein the external aqueous phase comprises water and an excipient, and wherein the excipient comprises a whey protein concentrate and a modified starch.

The present invention provides a method for manufacturing a water-in-oil-in-water multiple emulsion, comprising: (a) mixing an active component with an internal aqueous phase to form a homogenized mixture; (b) mixing the homogenized mixture with an oleaginous phase to form a water-in-oil emulsion; and (c) mixing the water-in-oil emulsion with an external aqueous phase to form the water-in-oil-in-water multiple emulsion, wherein the external aqueous phase comprises water and an excipient, and wherein the excipient comprises a whey protein concentrate and a modified starch.

The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.

According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a formulation for subcutaneous administration are provided so that pain can be relieved during administration to animals, and a chemical castration effect can last for 2 to 36 months. In addition, the present invention is effective as a chemical castration agent for 2 to 8 months so as to have an excellent of removing boar taint.

According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a formulation for subcutaneous administration are provided so that pain can be relieved during administration to animals, and a chemical castration effect can last for 2 to 36 months. In addition, the present invention is effective as a chemical castration agent for 2 to 8 months so as to have an excellent of removing boar taint.

A composition including a phosphorothioate oligonucleotide and at least one fatty acid and/or at least one emulsifying agent, where the composition is sterile and where the composition includes at least one agent including a thiol group and at least one phosphate compound, and the composition can be an ophthalmic composition. The present invention also relates to a method for obtaining the same and to the therapeutic use thereof.

A composition including a phosphorothioate oligonucleotide and at least one fatty acid and/or at least one emulsifying agent, where the composition is sterile and where the composition includes at least one agent including a thiol group and at least one phosphate compound, and the composition can be an ophthalmic composition. The present invention also relates to a method for obtaining the same and to the therapeutic use thereof.

The invention relates generally to vaccine compositions that are capable of eliciting and sustaining an immune response in a subject. The vaccine composition comprises a water-in-oil emulsion and a plurality of immunogen loaded hydrogel particles surrounded with a cationic polymer shell dispersed in the aqueous phase of the emulsion.

The efficacy in the use of probiotics is compromised due to their lack of survivability in gastric conditions (pH 1.5-3), leading to a large reduction in viable probiotic cells. The present disclosure describes cellulose nanocrystals (CNCs) modified with ferulic acid (FA) and shellac (SH) to produce two types of new coating materials, which are environment friendly and harmless to humans. These coating materials were developed and utilized to formulate Pickering emulsions (W.sub.1/O/W.sub.2 and W/O) for probiotic encapsulation. Based on their pKa values, greater than pKa, carboxyl groups from the CNCFA and CNCSH based Pickering emulsions were deprotonated, inducing phase separation and allow yeast releasing. This system could be further investigated for functionalized food-based applications to deliver active substances, such as probiotics, at high pH. Such delivery systems can be applied to human, animal, and aquatic systems.

The efficacy in the use of probiotics is compromised due to their lack of survivability in gastric conditions (pH 1.5-3), leading to a large reduction in viable probiotic cells. The present disclosure describes cellulose nanocrystals (CNCs) modified with ferulic acid (FA) and shellac (SH) to produce two types of new coating materials, which are environment friendly and harmless to humans. These coating materials were developed and utilized to formulate Pickering emulsions (W.sub.1/O/W.sub.2 and W/O) for probiotic encapsulation. Based on their pKa values, greater than pKa, carboxyl groups from the CNCFA and CNCSH based Pickering emulsions were deprotonated, inducing phase separation and allow yeast releasing. This system could be further investigated for functionalized food-based applications to deliver active substances, such as probiotics, at high pH. Such delivery systems can be applied to human, animal, and aquatic systems.