A process can be used for preparing nano- or microparticles containing a carrier-polymer and a biologically active ingredient. The process is a solvent emulsion process involving an organic phase (OP) and an aqueous phase (AP) to form an emulsion. In the case of an oil-in-water emulsion (O/W), the organic phase (OP) contains the biologically active ingredient dissolved or dispersed therein. Alternatively, in the case of a water-in-oil emulsion (W.sub.1/O), the aqueous phase (AP) contains the biologically active ingredient dissolved or dispersed therein. The organic phase (OP) is saturated with the salt-containing aqueous phase (AP) and vice versa.

The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules.

Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

A novel binder is provided. The binder comprises a polyvinyl alcohol-based polymer having an average saponification value of 96.0 mol% or more.

The present invention relates to a process for the production of a homogenous mixture of two or more branched chain keto acids wherein in a first step, two or more free keto acids are mixed, and in a second step, the mixed keto acids are co-crystallized with one or more alkaline earth metal salts, and foodstuff, food supplement or pharmaceutical products containing a mixture of branched-chain keto acids for supporting muscle structure, increasing muscle performance and improving general wellbeing with simultaneous relief of nitrogen detoxification metabolism by reduced nitrogen supply compared to the intake of the corresponding amino acids and an improved nitrogen metabolism in the body.

Disclosed is a composition for ameliorating, preventing or treating an autoimmune skin disease, containing a Musan box (Sphallerocarpus gracilis) extract or a fraction thereof as an active ingredient.

The present invention relates to methods for producing nanoparticle and microparticle powders of a biologically active material which have improved powder handling properties making the powders suitable for commercial use using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.

An anti-arrhythmic pharmaceutical composition. The pharmaceutical composition includes: an active ingredient, including 1-(3-methanesulfonamido benzyl)-6-methoxy, 7-benzyloxy-1,2,3,4-tetrahydroisoquinoline or a pharmaceutically acceptable salt thereof; and auxiliary materials, including lactose, microcrystalline cellulose and a pre-gelatinized starch, which account for 30% to 80% of the total weight of the composition. The composition has a good dissolution effect and excellent stability, and can be better applied to clinic.

Provided herein are low impurity compositions comprising a compound represented by Formula (I):

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which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

The present disclosure relates to, inter alia, improved methods for the treatment of solid tumors using embolic polymer microspheres, to embolic polymer microspheres that comprise a polymer and an inhibitor of the enzyme poly ADP ribose polymerase (PARP inhibitor) wherein the PARP inhibitor is held within the polymer microsphere and is elutable from the microsphere in aqueous media, and to methods of loading embolic polymer microspheres.