Pharmaceutical compositions of 4-((L-valyl)oxy)butanoic acid and the pharmacokinetics of 4-((L-valyl)oxy)butanoic acid and γ-hydroxybutyric acid following oral administration of the pharmaceutical compositions to healthy subjects are disclosed.

An insulation medium invention includes a plurality of microspheres. Each microsphere comprises a porous core comprising a porous core material and having an exterior surface, a gas within the porous core, and a coating layer coating all of the exterior surface of the porous core. The coating layer comprises a coating material which transitions from a first state to a second state. In the first state, the coating material is permeable to the gas. In the second state the material is impermeable to the gas. The coating material in the second state is configured to encapsulate and maintain partial vacuum of the gas inside the porous core. In one embodiment, in the second state the coating is impermeable to air. Insulated structures, a method of making an insulation medium, a fluid storage media, and a method of delivering a fluid are also disclosed.

A method of preventing progression of an appearance or effect of aging in a subject is provided. A method of preventing, limiting, or inhibiting injury to skin integrity in a subject is also provided. A method of substantially maintaining a state of skin integrity in a subject is further provided. A method of preventing a topographical change of a cutaneous layer of skin in a subject is still further provided. The methods comprise administering an effective amount of a preparation comprising ammonia oxidizing microorganisms to the subject. Related preparations and kits are also provided.

A medication of natural Chinese medicine with sustained release for cancer treatment and its preparation method thereof contains active ingredients of: ginsenoside, Astragalus polysaccharide, zedoary (Curcuma zedoaria), river bulrush (Sparganium stolonferum Buch.-Ham), Ternstroemia gymnanthera, Fructus Ligustri Lucidi, licorice, Chinese skullcap (Scutellaria baicalnsis Georgi), Sculellaria barbata, paclitaxel, Silybum marianum (L.) Gaertn., and Cannabidiol (CBD). The drug can restore body balance and promote self-recovery. The drug can be used as an alternative medicine or can be used in combination with conventional cancer treatment, and is especially target for patients suffered from toxic side effects of radiotherapy and chemotherapy, which can increase the efficiency and reduce the toxicity of conventional cancer treatment and eliminate side effects of vomiting, hair loss, and unbearable soreness of the body.

A device for the treatment of periodontal disease includes a handle that has a configuration familiar to dental professionals, and a detachable tip or cartridge, that is locked into the handle when use. The device provides for automatically delivering a single dose of medicament, such as a powdered preparation of antibiotic, to a periodontal pocket for treatment of infection or disease.

Described herein are transdermal formulations of phytocannabinoids and methods of using the same in the treatment of pain and/or inflammation.

The invention concerns an extruded depot form for sustained active substance release, comprising at least one active substance and at least one first compound from the class of biodegradable organic polymers based on lactic acid and/or glycolic acid.

A fluid storage media includes a plurality of microspheres. Each microsphere includes a porous core with a porous core material and having an exterior surface. A stored fluid is within the porous core. A coating layer covers all of the exterior surface of the porous core. The coating layer includes a coating material which transitions from a first state to a second state, wherein in the first state the coating material is permeable to the stored fluid, and in the second state the material is impermeable to the stored fluid. The coating material in the second state is configured to encapsulate and maintain the stored fluid inside the porous core. A method of making a fluid storage media, a method of delivering a fluid and a method of delivering a biologically active fluid medication to a patient are also disclosed.

Stabilized liquid agrochemical compositions are provided that comprise flowable, liquid dispersion concentrates comprising a) a continuous liquid phase; and b) a dispersed phase comprising a dispersion of gel-like polymer matrix particles having a hardness greater than 0.01 MPa and less than 6 MPa, and where the outside surfaces of the particles comprise a colloidal solid material and the particles have a agrochemically active ingredient distributed therein The agrochemically active ingredient may be solid or liquid and is distributed within the polymer matrix particle. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators.

Described herein are transdermal formulations of phytocannabinoids and methods of using the same in the treatment of pain and/or inflammation.