The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

A transdermal drug delivery device includes a reservoir, a transdermal membrane, a piston, a control rod, a spring, and a rotational cam. The reservoir is configured to hold a formulation. The transdermal membrane is configured to allow the formulation from the reservoir to pass therethrough. The piston is configured to move into the reservoir. The control rod is attached to the piston and includes a plurality of teeth thereon. The spring is configured to apply force to the control rod in the direction of the reservoir. The rotational cam has a first camming surface and a second camming surface that are configured to engage with the plurality of teeth. The rotational cam, when rotated, is configured to disengage the first camming surface from a first tooth of the plurality of teeth, thereby allowing the spring to advance the piston into the reservoir to expel the formulation onto the transdermal membrane.

The present disclosure generally relates to silicone-coated biophotonic material and to articles comprising same as well as to the potential uses thereof, such as, for example, in wound treatment.

The present disclosure provides a method of removing a cover from a bodily surface of a subject. The method may comprise applying a cover removal device to a portion of the cover that is disposed on the bodily surface of the subject, thereby generating a connection between the cover removal device and the portion of the cover. The method may comprise moving the cover removal device across the bodily surface of the subject in order to selectively remove the cover from the bodily surface and capture the cover onto the cover removal device, without the cover removal device substantially affecting or interfering with the bodily surface of the subject.

The present invention provides a packaging material for a patch, the packaging material comprising: an inner layer film made of a polyethylene terephthalate-based resin having heat sealing properties; and a substrate film, wherein a heat-sealing surface of the inner layer film comprises an isophthalic acid-modified polyethylene terephthalate resin having a copolymerization ratio of isophthalic acid component of 10 mol % to 20 mol %. More preferably, the inner layer film made of the polyethylene terephthalate-based resin having heat sealing properties is a multi-layer film comprising at least two layers including a heat sealing surface side layer made of an isophthalic acid-modified polyethylene terephthalate resin having a copolymerization ratio of isophthalic acid component of 10 mol % to 20 mol % and a layer made of an isophthalic acid-modified polyethylene terephthalate resin having a copolymerization ratio of isophthalic acid component of 0 mol % to 5 mol %.

Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-).sub.p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.

Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin.

The present invention relates to a UV-curable hydrogel resin for transdermal administration, a hydrogel prepared using the UV-curable hydrogel resin, and a cataplasm prepared using the UV-curable hydrogel resin. More particularly, the present invention relates to a hydrogel resin with an optimal composition and composition ratio which allows increase in a water content of a hydrogel applied as a drug layer of a cataplasm, skin irritation mitigation, and crosslinking degree adjustment for adhesion control and is capable of controlling drug releasing property and transdermal absorbability, a hydrogel prepared by UV-hardening the hydrogel resin, and a cataplasm including the hydrogel.

The present invention relates to a transdermal therapeutic system for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent- containing layer structure comprising: A) a backing layer; B) an active agent-containing layer comprising at least one silicone-containing polymer; C) a skin contact layer; and wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive.

The invention relates to a system containing: a transdermal therapeutic system (TTS); a cylindrical separating layer having an outer periphery and an inner periphery; and a backing layer, which is applied to the cylindrical separating layer and protrudes beyond the cylindrical separating layer over the entire periphery. The invention further relates to a system for improving the adhesion of a TTS, to the use of the system, and to a kit containing the system.