An object of the present invention is to provide a measure for treating or preventing a disease or condition that involves AMPK dysregulation, particularly a cancer. The present invention provides a combination therapy using a compound presented by formula (I), a pharmaceutically acceptable salt or a solvate thereof with an immune checkpoint inhibitor.

This patent document discloses compositions and methods related to anionic cannabinoid molecules that contain oxide substituents.

The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota β-glucuronidase, whereby providing potent activities to prevent chemotherapy-induced diarrhea (CID) of cancers. Therefore, the compounds of the present invention can be used as (1) chemotherapy-adjuvant to prevent chemotherapy-induced diarrhea (CID) and enhance chemotherapeutic efficiency of cancers; (2) health-food supplement to prevent the carcinogens induced colon carcinoma.

The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota β-glucuronidase, whereby providing potent activities to prevent chemotherapy-induced diarrhea (CID) of cancers. Therefore, the compounds of the present invention can be used as (1) chemotherapy-adjuvant to prevent chemotherapy-induced diarrhea (CID) and enhance chemotherapeutic efficiency of cancers; (2) health-food supplement to prevent the carcinogens induced colon carcinoma.

A composition in the form of dry powder for intranasal administration, having solid particles, each having a physiologically acceptable mucoadhesive polymer in combination with at least one functional additive such as pH adjusting agent, with at least about 90% of the particles having a size of about 25-300 microns, and various prophylactic and preventive uses thereof.

A composition in the form of dry powder for intranasal administration, having solid particles, each having a physiologically acceptable mucoadhesive polymer in combination with at least one functional additive such as pH adjusting agent, with at least about 90% of the particles having a size of about 25-300 microns, and various prophylactic and preventive uses thereof.

The present disclosure relates to relates to improved dietary supplement compositions formulated in a therapeutic effective amount for enhancing cognitive support and brain health. Specifically, the present disclosure relates to dietary and nutritional supplement compositions administered to a mammal in a therapeutically-effective amount to provide cognitive support and enhance overall brain health. The present disclosure further relates to a method of supporting cognitive health in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a nutritional supplement comprising a combination of a carotenoid and an adaptogen.

The present disclosure relates to relates to improved dietary supplement compositions formulated in a therapeutic effective amount for enhancing cognitive support and brain health. Specifically, the present disclosure relates to dietary and nutritional supplement compositions administered to a mammal in a therapeutically-effective amount to provide cognitive support and enhance overall brain health. The present disclosure further relates to a method of supporting cognitive health in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a nutritional supplement comprising a combination of a carotenoid and an adaptogen.