The invention provides novel compounds having the general formula I:

##STR00001##

wherein R.sup.1, R.sup.2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula I:

##STR00001##

wherein R.sup.1, R.sup.2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula I: ##STR00001##
wherein R.sup.1, R.sup.2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula I: ##STR00001##
wherein R.sup.1, R.sup.2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

A combination comprising an effective dose of a chemotherapeutic-activating wild-type bacterium and an effective dose of a chemotherapeutic agent that is responsive to the chemotherapeutic activating wild-type bacterium, for use in a method of preventing or treating a solid tumour cancer in a mammal.

In response to the threat of global pandemics and bacterial species becoming increasingly resistant to antibiotic attack, this invention provides systems and methods for reducing the infectivity of bacteria and viruses in the human body by introducing onto the human body or into the human body or onto personal protective equipment or any combination thereof aqueous solutions containing a combination of solutes that simultaneously chemically modify bacterial and viral proteins so as to disrupt their normal function and disrupt the physical integrity of bacterial and viral lipid membranes by providing destabilizing pH, disulfide bond reduction capability, lipid membrane disruption (detergent) capability, hyperosmotic stress and interference with the binding of viral or bacterial proteins to cellular surface proteins.

In response to the threat of global pandemics and bacterial species becoming increasingly resistant to antibiotic attack, this invention provides systems and methods for reducing the infectivity of bacteria and viruses in the human body by introducing onto the human body or into the human body or onto personal protective equipment or any combination thereof aqueous solutions containing a combination of solutes that simultaneously chemically modify bacterial and viral proteins so as to disrupt their normal function and disrupt the physical integrity of bacterial and viral lipid membranes by providing destabilizing pH, disulfide bond reduction capability, lipid membrane disruption (detergent) capability, hyperosmotic stress and interference with the binding of viral or bacterial proteins to cellular surface proteins.

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.