A61K31/396

Aziridine containing DNA alkylating agents

Provided herein are compounds of formula (I)-(VI): ##STR00001##
wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

Aziridine containing DNA alkylating agents

Provided herein are compounds of formula (I)-(VI): ##STR00001##
wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

DETERMINING SMALL MOLECULE-PROTEIN AND PROTEIN-PROTEIN INTERACTIONS

Provided herein are methods, systems, kits, and compositions useful for determining small molecule-protein interactions and protein-protein interactions. The photo-click tags provided herein can be conjugated to a small molecule or amino acid analog to provide compounds that can be integrated into a protein through photo-conjugation, allowing for identification of a small molecule-protein interaction or protein-protein interaction to elucidate the small molecules mechanism of action or the protein targeted by the small molecule. In some embodiments, the photo-click tags comprise a photo-conjugation moiety and a click chemistry handle, allowing for the attachment of various functional groups (e.g., affinity tags) to the small molecule or amino acid analog.

ANTI-FUGETACTIC AGENT AND ANTI-CANCER AGENT COMBINATION THERAPY AND COMPOSITIONS FOR THE TREATMENT OF CANCER
20200093928 · 2020-03-26 ·

The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

ANTI-FUGETACTIC AGENT AND ANTI-CANCER AGENT COMBINATION THERAPY AND COMPOSITIONS FOR THE TREATMENT OF CANCER
20200093928 · 2020-03-26 ·

The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

ANTI-FUGETACTIC AGENT AND ANTI-CANCER AGENT COMBINATION THERAPY AND COMPOSITIONS FOR THE TREATMENT OF CANCER
20200093928 · 2020-03-26 ·

The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

AZIRIDINE CONTAINING DNA ALKYLATING AGENTS

Provided herein are compounds of formula (I)-(VI):

##STR00001##

wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

AZIRIDINE CONTAINING DNA ALKYLATING AGENTS

Provided herein are compounds of formula (I)-(VI):

##STR00001##

wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

NOVEL ARYL ETHENE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.

NOVEL ARYL ETHENE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.