Disclosed herein are compositions useful for treating hypogonadism in men and women. The disclosed compositions comprise an admixture of testosterone and triamcinolone which combination alleviates pellet injection site pain and/or discomfort, as well as pellet extrusion.

Disclosed herein are compositions useful for treating hypogonadism in men and women. The disclosed compositions comprise an admixture of testosterone and triamcinolone which combination alleviates pellet injection site pain and/or discomfort, as well as pellet extrusion.

This invention relates to methods of treating adjustment disorders, particularly adjustment disorder with anxiety (AjDA), in an individual include administering a therapeutically effective amount of an androsta-4,16-dien-3-ol steroid to the individual. In some embodiments of the methods, a therapeutically effective amount of an androsta-4,16-dien-3-ol steroid is administered to a patient, and in some embodiments of the compositions, a therapeutically effective amount of an androsta-4,16-dien-3-ol is included in a pharmaceutical composition for the treatment of AjDA.

This invention relates to methods of treating adjustment disorders, particularly adjustment disorder with anxiety (AjDA), in an individual include administering a therapeutically effective amount of an androsta-4,16-dien-3-ol steroid to the individual. In some embodiments of the methods, a therapeutically effective amount of an androsta-4,16-dien-3-ol steroid is administered to a patient, and in some embodiments of the compositions, a therapeutically effective amount of an androsta-4,16-dien-3-ol is included in a pharmaceutical composition for the treatment of AjDA.

The invention relates to methods for treatment of bone fractures and defects, in particular to method that accelerate fracture healing, and to compositions, injectable in situ depot forming formulations and patches comprising at least one biodegradable polymer, an androgen receptor agonist and a bisphosphonate or pharmaceutically acceptable salt thereof for use in such methods.

The invention relates to methods for treatment of bone fractures and defects, in particular to method that accelerate fracture healing, and to compositions, injectable in situ depot forming formulations and patches comprising at least one biodegradable polymer, an androgen receptor agonist and a bisphosphonate or pharmaceutically acceptable salt thereof for use in such methods.

The invention relates to methods for treatment of bone fractures and defects, in particular to method that accelerate fracture healing, and to compositions, injectable in situ depot forming formulations and patches comprising at least one biodegradable polymer, an androgen receptor agonist and a bisphosphonate or pharmaceutically acceptable salt thereof for use in such methods.

The present disclosure describes a method for treating a disease or condition selected from Parkinson's disease, traumatic brain injury, concussion, chronic traumatic encephalopathy, spinal cord injury, Sjögren's syndrome, Hashimoto's disease, lupus, psoriasis, psoriatic arthritis, rheumatoid arthritis, graft vs. host disease, hypogonadism, male metabolic syndrome, menopausal hormone insufficiency, and ocular surface disease, the method comprising topical administration of a testosterone composition to the forehead.

The present disclosure describes a method for treating a disease or condition selected from Parkinson's disease, traumatic brain injury, concussion, chronic traumatic encephalopathy, spinal cord injury, Sjögren's syndrome, Hashimoto's disease, lupus, psoriasis, psoriatic arthritis, rheumatoid arthritis, graft vs. host disease, hypogonadism, male metabolic syndrome, menopausal hormone insufficiency, and ocular surface disease, the method comprising topical administration of a testosterone composition to the forehead.

The present disclosure describes a method for treating a disease or condition selected from Parkinson's disease, traumatic brain injury, concussion, chronic traumatic encephalopathy, spinal cord injury, Sjögren's syndrome, Hashimoto's disease, lupus, psoriasis, psoriatic arthritis, rheumatoid arthritis, graft vs. host disease, hypogonadism, male metabolic syndrome, menopausal hormone insufficiency, and ocular surface disease, the method comprising topical administration of a testosterone composition to the forehead.