The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.

The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.

An implantable and refillable device for delivering a drug compound is provided. The device comprises a reservoir within which the drug compound is capable of being retained, wherein the reservoir defines a first surface and a second surface opposing the first surface. A release structure comprising a hydrophobic polymer surrounds at least a portion of the reservoir. The release structure is in communication with the reservoir such that the drug compound can pass from the reservoir through the release structure. A septum is positioned adjacent to the first surface of the reservoir and a backing layer is positioned adjacent to the second surface of the reservoir.

An implantable and refillable device for delivering a drug compound is provided. The device comprises a reservoir within which the drug compound is capable of being retained, wherein the reservoir defines a first surface and a second surface opposing the first surface. A release structure comprising a hydrophobic polymer surrounds at least a portion of the reservoir. The release structure is in communication with the reservoir such that the drug compound can pass from the reservoir through the release structure. A septum is positioned adjacent to the first surface of the reservoir and a backing layer is positioned adjacent to the second surface of the reservoir.

The present invention provides a combination therapy for treating a tumor in a subject. The combination comprises two elements. The first is a polypeptide construct comprising an attenuated Type 1 interferon (IFN) linked to an antibody which binds to a cell surface-associated antigen expressed on the tumour cell and comprising a functional Fc region. The second is a CD47 antagonist which inhibits the interaction CD47 with the SIRPα receptor.

The present invention provides a composition and method of treating infection-induced cardiomyopathy in a subject, the method comprising administering to the subject a therapeutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically effective salt thereof, wherein the nitrogen-containing bisphosphonate is useful as a therapeutic agent, in particular in the treatment, therapy or prophylaxis of the novel coronavirus COVID-19.

The present invention provides a composition and method of treating infection-induced cardiomyopathy in a subject, the method comprising administering to the subject a therapeutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically effective salt thereof, wherein the nitrogen-containing bisphosphonate is useful as a therapeutic agent, in particular in the treatment, therapy or prophylaxis of the novel coronavirus COVID-19.

The present invention provides a composition and method of treating infection-induced cardiomyopathy in a subject, the method comprising administering to the subject a therapeutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically effective salt thereof, wherein the nitrogen-containing bisphosphonate is useful as a therapeutic agent, in particular in the treatment, therapy or prophylaxis of the novel coronavirus COVID-19.

Provided is use of a nitrogen-containing bisphosphonate in combination with a glucocorticoid in preventing or treating viral pneumonia. Specifically, provided is a nitrogen-containing bisphosphonate in combination with a glucocorticoid for use in treating or ameliorating coronavirus infections, the nitrogen-containing bisphosphonate is selected from the group consisting of pamidronate, alendronate, risedronate, ibandronate, zoledronate, minodronate and incadronate. The glucocorticoid is selected from the group consisting of dexamethasone, rimexolone, prednisolone, fluorometholone, hydrocortisone, mometasone, fluticasone, beclomethasone, flunisolide, triamcinolone, fluticasone propionate, beclomethasone dipropionate, budesonide and mometasone furoate.

Provided is use of a nitrogen-containing bisphosphonate in combination with a glucocorticoid in preventing or treating viral pneumonia. Specifically, provided is a nitrogen-containing bisphosphonate in combination with a glucocorticoid for use in treating or ameliorating coronavirus infections, the nitrogen-containing bisphosphonate is selected from the group consisting of pamidronate, alendronate, risedronate, ibandronate, zoledronate, minodronate and incadronate. The glucocorticoid is selected from the group consisting of dexamethasone, rimexolone, prednisolone, fluorometholone, hydrocortisone, mometasone, fluticasone, beclomethasone, flunisolide, triamcinolone, fluticasone propionate, beclomethasone dipropionate, budesonide and mometasone furoate.