Disclosed herein are methods for imaging a tissue in a subject that involves administering to the subject a composition comprising deuterium-labeled glycolytic or fatty acid substrate and imaging the subject with deuterium magnetic resonance imaging (DMI) to detect hydrogen-deuterium oxide (HDO) in tissues of the subject. The disclosed methods can be used to detect changes in metabolic activity in a tissue. The disclosed methods can also be used to detect cancers.

The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging.

[Problem] To provide a nuclear magnetic resonance diagnostic agent that has a lower toxicity to organisms and reduced side effects and yet has a site specificity toward a specific cell, tissue, organ, etc. [Solution] When ALA or an ALA derivative is administered in vivo, a metabolite thereof is accumulated in a specific cell, tissue, organ, etc. Focusing on this phenomenon, a nuclear magnetic resonance analysis was performed on a site wherein the metabolite of ALA that had been administered in vivo would be possibly accumulated. As a result, it was surprisingly found that ALA and an ALA derivative are useful as a diagnostic agent whereby the aforesaid problem can be solved.

A computerized information processing method for evaluating blood vessels is provided. The method includes acquiring a series of sequences of measurements, each at different time points in at least one cardiac cycle and at a different point along a blood vessel segment of a subject, generating corresponding profiles, calculating a transfer function for a subsegment between two selected points along a blood flow direction, and based thereon determining the physiological property of the subsegment. The measurements can contain information of blood velocity or blood pressure. A processing device and system implementing the information processing method are also provided. This approach can be used to evaluate arteries or veins and can be applied in screening, diagnosis, or prognosis of a variety of vascular diseases. For example, when combined with MRI scan, this approach can be used for non-invasively diagnosing pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), etc.

An article of manufacture for providing an onboard vehicle recharging environment according to the present invention is disclosed. A Continuous Onboard Recharging Environment (CORE) translates mechanical rotational energy obtained from the rotating axles of a vehicle to a form of sufficient voltage and load amperage to facilitate the charging of an Electric Vehicle's battery system while the vehicle is in operation, thus reducing or removing the need for external charging.

The disclosure relates to the acceleration of MRI examinations, particularly during the detection and differential diagnosis of focal liver lesions by way of dynamic contrast-enhanced magnetic resonance imaging (MRI). The disclosure also relates to a method, a system and a computer program product for generating MRI images, particularly of the liver.

There is provided a microparticle composition suitable for molecular imaging, the composition comprising microparticles, wherein the microparticles comprise: a core microparticle structure having a central area and a shell, and wherein the core microparticle structure comprises (i) a phosphatidylcholine lipid: (ii) a phosphatidylethanolamine lipid comprising at least one maleimide moiety; and (iii) an alkoxylated fatty acid.

A plurality of reception coils are used to acquire magnetic resonance signals using parallel imaging and a k-space acquisition scheme, in which alternatingly the central region and one of the peripheral k-space portions are imaged in acquisition steps of a pair, such that after a partition number of such pairs, the whole k-space to be acquired has been imaged and a sliding reconstruction window can be applied to reconstruct an additional magnetic resonance image after each acquisition of such a pair. A time series of magnetic resonance images forming the magnetic resonance data set is then reconstructed from the magnetic resonance signals and sensitivity information regarding the plurality of reception coils by using the sliding reconstruction window and a reconstruction technique for undersampled magnetic resonance data. The k-space trajectories for each acquisition step are chosen to allow controlled aliasing in all three spatial dimensions including the readout direction.

A method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is [1-.sup.13C] N-acetyl cysteine, a deuterated derivative thereof, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient; and diagnosing or monitoring the patient by hyperpolarized .sup.13C-MRI. Also disclosed is a method of synthesizing [1-.sup.13C] N-acetyl cysteine or a deuterated derivative thereof.

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.