The invention provides for a medical imaging system (100, 300). The medical imaging system (100, 300) comprises a processor (104). Execution of machine executable instructions (120) causes the processor (104) to: receive magnetic resonance data, wherein the magnetic resonance data comprises B0 field data (122) of a reference scan for a plurality of voxels and water saturation data (124) of a WASSR scan for a subset of voxels of the plurality of voxels, the water saturation data (124) comprising data of a limited number of sample points; determine a local absolute water saturation frequency (130) for each voxel of the subset using the water saturation data (124) of the WASSR scan; and reconstruct a field map (132) comprising a local absolute water saturation frequency for each voxel of the plurality of voxels, wherein the reconstruction comprises determining relative frequency differences between the voxels using the B0 field data (122) of the reference scan and adding a frequency offset to the relative frequency differences based on the determined local absolute water saturation frequencies (130) of the subset.

A medical analysis system (111) for processing magnetic resonance imaging (MRI), data (170) from a target volume (208) in a subject (218) includes a memory (107) for storing machine executable instructions; and a processor (103) for controlling the system (111). Execution of the machine executable instructions causes the processor (103) to: determine from the MRI data (103) chemical exchange saturation transfer (CEST) voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weight the CEST values in order to distinguish CEST values of fluid-rich tissues (507) from CEST values of solid tissues (505) in the target volume (208), wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid.

The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.

A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system and a radiofrequency generator synchronized by a processing system is disclosed. The system is capable of identifying health condition-specific Hdp variation values changes in a patient upon the exposure of low energy amplitude modulated electromagnetic fields frequencies. A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system, a radiofrequency generator synchronized by a processing system, and a chemical exchange saturation transfer (CEST)-MRI system is further disclosed. The exposure of the modulated frequencies influences cellular functions, such as microtubule conductivity or cellular metabolism, 1460 or malfunctions in a patient and can provide both a therapeutic and predictive and prognostic effect for the patient, providing for both treatment of a specific ailment or disease such as hepatocellular carcinoma as well as predictive results of how effective the treatment is likely to be. The construction of a library of frequencies can be used to more efficiently and effectively diagnose and treat a health condition in patients by auto-tuning a treatment regimen specifically to the patient.

A magnetic resonance imaging apparatus according to one embodiment includes sequence control circuitry and processing circuitry. The sequence control circuitry performs a first data acquisition for chemical shift measurement and a second data acquisition for either chemical shift measurement or MR imaging, which differs from chemical shift measurement, on the same subject under certain conditions that differ between those data acquisitions. The processing circuitry performs medical data classification on the subject based on first MR data obtained through the first data acquisition and second MR data obtained through the second data acquisition.

An apparatus and method are provided for transmitting control information and data in a DFT based communication system. The method includes placing a reference signal onto a first symbol among a plurality of symbols in one slot; placing a HARQ-ACK onto a second symbol first placed after the first symbol in the one slot; placing the data onto other symbols except for the first symbol; and transmitting a signal including the reference signal, the HARQ-ACK and the data. A part of CQI information is further placed onto at least one symbol, except for the first symbol, in case that the CQI information is present for transmission in the one slot.

One or more example embodiments of the present invention relates to a method for generating a subject-specific map of a tissue property, in particular the magnetic susceptibility, of a region of interest within a subject, the method comprising receiving an MR image of the region of interest; inputting the MR image as input into at least one trained neural network, wherein the output of the neural network is an output image having improved contrast between bone and air; segmenting the output image into air and at least bone and at least one type of soft tissue to obtain a segmented image; and assigning pre-determined values for the tissue property to each category of tissue and air in the segmented image to obtain the subject-specific map of the tissue property.

The present disclosure provides a system for MRI. The system may obtain a plurality of echo signals relating to a subject that are excited by an MRI pulse sequence applied to the subject. The system may perform a quantitative measurement on the subject based on the plurality of echo signals. The MRI pulse sequence may include a CEST module configured to selectively excite exchangeable protons or exchangeable molecules in the subject, an RF excitation pulse applied after the CEST module configured to excite a plurality of gradient echoes, and one or more refocusing pulses applied after the RF excitation pulse. Each of the refocusing pulses may be configured to excite one or more spin echoes. The one or more spin echoes excited by at least one of the one or more refocusing pulses may include a symmetric spin echo and one or more asymmetric spin echoes.

There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.

This invention relates to disease detection by imaging and treatment of virus infection. Previously, there was no way to use CEST MRI imaging to early detect and map the neurodegenerative diseases, multiple sclerosis disease, concussion, and traumatic brain injury. Also, previously, there was no way to use Computed Tomography (CT) imaging to early detect and map the neurodegenerative diseases. Embodiments of the present invention use a non-invasive CEST MRI imaging method is disclosed for early detection of diseases by using MRI or by using CT. The endogenous (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of the neurodegenerative diseases, multiple sclerosis disease, concussion, traumatic brain injury, and other diseases by using endogenous protons contrast via CEST MRI. Also, the exogenous agents can be used to produce MRI contrast, such as agents contain exchangeable protons and thereby provide imaging and mapping the inflammation in cancer and the expressed proteins in cancer cells for cancer detection. Also, using exogenous CT contrast agents for detection of amyloid beta, tau protein, alpha-synuclein protein, and aggregation proteins in neurodegenerative diseases and inflammation in many diseases such as neurodegenerative diseases, cancer and other inflammatory diseases Also, this invention relates to novel methods of treatment virus infection and enhance the immune system to produce antibodies against the viruses.