The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing, causing or increasing weight loss, treating obesity and/or treating metabolic syndrome utilizing the modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of improving insulin sensitivity and glycemic control, reducing insulin levels and/or improving leptin sensitivity utilizing the modified or polymer conjugated MetAP2 inhibitors.

The invention relates to the field of medicine, particularly to a method for increasing blood haemoglobin level in a cancer patient. A method for increasing blood haemoglobin level in a cancer patient, wherein a pharmaceutical composition comprising a poloxamer as a pharmacologically active substance is administered before and/or during and/or after a course of the chemotherapy or immunotherapy is provided. Thus, the claimed invention provides such a method for increasing blood haemoglobin level in a cancer patient, implementation of which ensures the achievement of the technical result consisting in normalization and maintaining patient's general physical condition at a level that allows for chemotherapy and immunotherapy courses to be administered and improves patients general physical condition following the treatment of cancer with simultaneous reduction of a toxic effect and side effects on a patients

The invention relates to the field of medicine, particularly to a method for increasing blood haemoglobin level in a cancer patient. A method for increasing blood haemoglobin level in a cancer patient, wherein a pharmaceutical composition comprising a poloxamer as a pharmacologically active substance is administered before and/or during and/or after a course of the chemotherapy or immunotherapy is provided. Thus, the claimed invention provides such a method for increasing blood haemoglobin level in a cancer patient, implementation of which ensures the achievement of the technical result consisting in normalization and maintaining patient's general physical condition at a level that allows for chemotherapy and immunotherapy courses to be administered and improves patients general physical condition following the treatment of cancer with simultaneous reduction of a toxic effect and side effects on a patients

The invention provides a colon cleansing solution comprising:

a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and
b) 10 to 200 g per litre polyethylene glycol.

The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.

The invention provides a colon cleansing solution comprising:

a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and
b) 10 to 200 g per litre polyethylene glycol.

The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.

The invention provides a colon cleansing solution comprising:

a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and
b) 10 to 200 g per litre polyethylene glycol.

The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.

The present invention concerns the field of medications for the treatment of lesions and wounds of the skin and mucosa. The present invention relates to the use of a composition comprising a combination of a mucoadhesive component in the range from 0.05-20% by weight, an emollient component in the range from 0.02-20% by weight, hydrating and mucoprotective component i.e. hyaluronic acid in the range from 0.01-15% by weight and epithelizing component i.e. one or more amino acids in the range from 0.02-5% by weight in the treatment of epithelial lesions. The invention further comprises a composition comprising: —carbomer (poly acrylic acid) in the range from 0.05% to 5%; —sodium hyaluronate in the range from 0.01% to 15%; —poloxamer (copolymers of ethylene oxide and propylene oxide) in the range from 0.1% to 15%; —Oryza sativa extract in the range from 0.2% to 20%; and —one or more amino acids in the range from 0.025% to 5%, wherein said percentages are by weight of the total weight of the product (w/w).

The present invention concerns the field of medications for the treatment of lesions and wounds of the skin and mucosa. The present invention relates to the use of a composition comprising a combination of a mucoadhesive component in the range from 0.05-20% by weight, an emollient component in the range from 0.02-20% by weight, hydrating and mucoprotective component i.e. hyaluronic acid in the range from 0.01-15% by weight and epithelizing component i.e. one or more amino acids in the range from 0.02-5% by weight in the treatment of epithelial lesions. The invention further comprises a composition comprising: —carbomer (poly acrylic acid) in the range from 0.05% to 5%; —sodium hyaluronate in the range from 0.01% to 15%; —poloxamer (copolymers of ethylene oxide and propylene oxide) in the range from 0.1% to 15%; —Oryza sativa extract in the range from 0.2% to 20%; and —one or more amino acids in the range from 0.025% to 5%, wherein said percentages are by weight of the total weight of the product (w/w).

The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.