The subject of the present invention is cosmetic or pharmaceutical compositions which are protective against common skin irritants or allergens. The invention is also directed to the use of these compositions to protect skin from the effects of metal. Another object of the invention is a method of preventing or protecting the skin from the effects of metal, using the compositions of the invention.

The subject of the present invention is cosmetic or pharmaceutical compositions which are protective against common skin irritants or allergens. The invention is also directed to the use of these compositions to protect skin from the effects of metal. Another object of the invention is a method of preventing or protecting the skin from the effects of metal, using the compositions of the invention.

The invention provides CaO.sub.2 nanoparticles having a pH-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxygen to exert their effect, such as photodynamic therapy (PDT), sonodynamic therapy (SDT), and radiotherapy. The invention also provides pharmaceutical compositions containing the coated CaO.sub.2 nanoparticles, together with at least one photosensitiser, sonosensitiser, or radiosensitiser and, optionally, at least one pharmaceutical carrier or excipient.

The invention provides CaO.sub.2 nanoparticles having a pH-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxygen to exert their effect, such as photodynamic therapy (PDT), sonodynamic therapy (SDT), and radiotherapy. The invention also provides pharmaceutical compositions containing the coated CaO.sub.2 nanoparticles, together with at least one photosensitiser, sonosensitiser, or radiosensitiser and, optionally, at least one pharmaceutical carrier or excipient.

One aspect of the present invention relates generally to injectable compositions. In one embodiment, the compositions include 2-hydroxyethyl methacrylate and a dimethacrylate crosslinker. Another aspect of the invention relates generally to methods of using such compositions for thermal ablation and for the occlusion of body vessels.

One aspect of the present invention relates generally to injectable compositions. In one embodiment, the compositions include 2-hydroxyethyl methacrylate and a dimethacrylate crosslinker. Another aspect of the invention relates generally to methods of using such compositions for thermal ablation and for the occlusion of body vessels.

The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group with a GAG comprising a terminal primary amine.

The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group with a GAG comprising a terminal primary amine.

The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group with a GAG comprising a terminal primary amine.

Provided are biocompatible topical compositions including a novel combination of an inflammatory management agent, a vascular repair agent, a neurogenic agent, a sebum suppression agent and an exfoliating agent. Also provided are methods for treating, preventing or ameliorating rosacea, a symptom thereof or a condition related thereto by administering the biocompatible topical compositions describe herein.