This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CDS 4+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

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This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CDS 4+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

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Provided herein are methods of using multipotent stem cells in treatment or prophylaxis of disease, in a system for improving general health and overall wellness. The disclosure provides a method in which multipotent stem cells are intravenously administered within the oral cavity, which has a rapid effect on symptoms of inflammation and/or infection, not only treating periodontal diseases, but also reducing bacterial load, pain, bone loss, etc. as well as stimulating new bone growth and achieving other hallmarks of improvement in health and overall systemic wellness. In some instances, a sample of a bodily fluid is drawn from the patient before injection to measure baseline levels of several biomarkers to obtain the patient's status on the spectrum of health and wellness and/or to compare post-treatment effects of the injected stem cells, to measure improvement, and to develop a treatment plan for enhancing multisystem wellness.

Provided herein are methods of using multipotent stem cells in treatment or prophylaxis of disease, in a system for improving general health and overall wellness. The disclosure provides a method in which multipotent stem cells are intravenously administered within the oral cavity, which has a rapid effect on symptoms of inflammation and/or infection, not only treating periodontal diseases, but also reducing bacterial load, pain, bone loss, etc. as well as stimulating new bone growth and achieving other hallmarks of improvement in health and overall systemic wellness. In some instances, a sample of a bodily fluid is drawn from the patient before injection to measure baseline levels of several biomarkers to obtain the patient's status on the spectrum of health and wellness and/or to compare post-treatment effects of the injected stem cells, to measure improvement, and to develop a treatment plan for enhancing multisystem wellness.

Provided herein are methods of using multipotent stem cells in treatment or prophylaxis of disease, in a system for improving general health and overall wellness. The disclosure provides a method in which multipotent stem cells are intravenously administered within the oral cavity, which has a rapid effect on symptoms of inflammation and/or infection, not only treating periodontal diseases, but also reducing bacterial load, pain, bone loss, etc. as well as stimulating new bone growth and achieving other hallmarks of improvement in health and overall systemic wellness. In some instances, a sample of a bodily fluid is drawn from the patient before injection to measure baseline levels of several biomarkers to obtain the patient's status on the spectrum of health and wellness and/or to compare post-treatment effects of the injected stem cells, to measure improvement, and to develop a treatment plan for enhancing multisystem wellness.

An embodiment provides a method for treating a body fluid of a patient, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with an aging process targeted antigen (TA) in the body fluid to form an antibody-TA complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-antigen complex from the body fluid; and returning the body fluid to the patient. Other aspects are described and claimed.

An embodiment provides a method for treating a body fluid of a patient, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with an aging process targeted antigen (TA) in the body fluid to form an antibody-TA complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-antigen complex from the body fluid; and returning the body fluid to the patient. Other aspects are described and claimed.

The present disclosure provides a method of treating mitochondrial and age-related diseases and disorders with exercised blood products. The blood products include circulating factors whose production or secretion into the blood is stimulated by exercise.

The present disclosure provides a method of treating mitochondrial and age-related diseases and disorders with exercised blood products. The blood products include circulating factors whose production or secretion into the blood is stimulated by exercise.

A method for treating cancer by treating target cancer cells with cold atmospheric plasma to induce apoptosis of the target cancer cells through the degradation of Histone RNA during S-phase induced by oxidation of RNA.