Disclosed herein are hepato-biliary-pancreatic organoid (HBPO or HBP organoid) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.

Disclosed herein are hepato-biliary-pancreatic organoid (HBPO or HBP organoid) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.

Provided in the present disclosure is a method of treating heart failure and a traditional Chinese medicine composition for treating heart failure, the method of treating heart failure including administrating to a subject an amount of a traditional Chinese medicine composition, in which the traditional Chinese medicine composition includes following components in terms of parts by weight: 46-53.6 parts of Semen Myristicae, 42.4-49.2 parts of Radix Vladimiriae, 98.4-111.6 parts of Fructus Chebulae, 50.8-65.2 parts of Stigma Croci, 17.2-26 parts of Bovis Calculus, and 9.2-13.6 parts of bear bile powder. The aforementioned traditional Chinese medicine composition enhances the efficacy of the medicine and broadens the scope of treatment by ingeniously combining a variety of traditional Chinese medicinal ingredients, which achieves concurrent regulation of qi, blood, yin and yang, and simultaneous treatment of the organs, effectively exerting therapeutic effects on heart failure.

Provided in the present disclosure is a method of treating heart failure and a traditional Chinese medicine composition for treating heart failure, the method of treating heart failure including administrating to a subject an amount of a traditional Chinese medicine composition, in which the traditional Chinese medicine composition includes following components in terms of parts by weight: 46-53.6 parts of Semen Myristicae, 42.4-49.2 parts of Radix Vladimiriae, 98.4-111.6 parts of Fructus Chebulae, 50.8-65.2 parts of Stigma Croci, 17.2-26 parts of Bovis Calculus, and 9.2-13.6 parts of bear bile powder. The aforementioned traditional Chinese medicine composition enhances the efficacy of the medicine and broadens the scope of treatment by ingeniously combining a variety of traditional Chinese medicinal ingredients, which achieves concurrent regulation of qi, blood, yin and yang, and simultaneous treatment of the organs, effectively exerting therapeutic effects on heart failure.

Provided is a compound hydrocortisone and neomycin sulfate granule, including the following components in parts by mass: 140 parts of acetaminophen, 1 part of chlorpheniramine maleate, 1.2 parts of methylephedrine hydrochloride, 2 to 2.5 parts of an inclusion stabilizer, 3.0 parts of artificial calculus bovis, and 0.5 to 1 parts of a caramel. In a method for preparing the compound hydrocortisone and neomycin sulfate granule, natural Chinese medicinal herbs are subjected to extraction to obtain natural stabilizers for stabilizing low-concentration acetaminophen and chlorpheniramine maleate, and the natural stabilizers are encapsulated with hydroxypropyl--cyclodextrin with a specific degree of substitution (DS).

Provided is a compound hydrocortisone and neomycin sulfate granule, including the following components in parts by mass: 140 parts of acetaminophen, 1 part of chlorpheniramine maleate, 1.2 parts of methylephedrine hydrochloride, 2 to 2.5 parts of an inclusion stabilizer, 3.0 parts of artificial calculus bovis, and 0.5 to 1 parts of a caramel. In a method for preparing the compound hydrocortisone and neomycin sulfate granule, natural Chinese medicinal herbs are subjected to extraction to obtain natural stabilizers for stabilizing low-concentration acetaminophen and chlorpheniramine maleate, and the natural stabilizers are encapsulated with hydroxypropyl--cyclodextrin with a specific degree of substitution (DS).

Disclosed herein are hepato-biliary-pancreatic organoid (HBPO or HBP organoid) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.

Disclosed herein are hepato-biliary-pancreatic organoid (HBPO or HBP organoid) compositions, and methods of making and using hepato-biliary-pancreatic organoid compositions. The disclosed compositions may have two or more functions selected from hepatic tissue function, biliary tissue function, exocrine pancreatic function, and endocrine pancreatic tissue function. Methods of treating individuals using the hepato-biliary-pancreatic organoid compositions is also disclosed.