Provided herein are compositions containing dehydrated placental tissue particulates, methods of making the compositions and methods for treating various musculoskeletal disorders and other conditions using such compositions, including osteoarthritis (OA), degenerative disc disease, tendonitis, plantar fasciitis, and pain associated therewith.

The present invention provides universal donor cellular populations derived from umbilical cords possessing ability to elicit immune modulation and evoke regeneration when administered into a mammalian host. Generation of cellular products for clinical use are provided including methodologies of expansion, characterization, and means of therapeutic implementation.

The present invention provides universal donor cellular populations derived from umbilical cords possessing ability to elicit immune modulation and evoke regeneration when administered into a mammalian host. Generation of cellular products for clinical use are provided including methodologies of expansion, characterization, and means of therapeutic implementation.

The present invention relates to a cord blood plasma-derived exosome or a mimetic thereof and a pharmaceutical use thereof. More particularly, the present invention provides the use of a human cord blood plasma-derived exosome or an exosome mimetic that mimics the proteomic profile of the cord blood plasma-derived exosome for the improvement, prevention or treatment of various autoimmune diseases or wound healing.

The present invention relates to a cord blood plasma-derived exosome or a mimetic thereof and a pharmaceutical use thereof. More particularly, the present invention provides the use of a human cord blood plasma-derived exosome or an exosome mimetic that mimics the proteomic profile of the cord blood plasma-derived exosome for the improvement, prevention or treatment of various autoimmune diseases or wound healing.

The present invention relates to the field of manufacturing of Natural Killer (NK) Cells genetically modified with viral vectors carrying a polynucleotide coding for a Chimeric Antigen Receptors (CARs). The present invention further relates to CAR-NK cells obtained with the method and use of the CAR-NK cells in medicine, in particular for use in a method of treating cancer.

The present disclosure provides expression constructs designed to provide for expression of therapeutic proteins from engineered cells. The engineered cells may be encapsulated into implantable elements that allow for the therapeutic protein to be released into from the capsule while protecting the cell from the immune system of a patient into which the capsule is implanted.

This document provides methods and materials for using umbilical cord blood to treat non-malignant disorders. For example, methods and materials for administering umbilical cord blood to a mammal (e.g., a human) via multiple (e.g., two or more) infusions to treat non-malignant diseases such as inherited disorders of metabolism, immunity, and/or hematopoiesis are provided.

This document provides methods and materials for using umbilical cord blood to treat non-malignant disorders. For example, methods and materials for administering umbilical cord blood to a mammal (e.g., a human) via multiple (e.g., two or more) infusions to treat non-malignant diseases such as inherited disorders of metabolism, immunity, and/or hematopoiesis are provided.

This document provides methods and materials for using umbilical cord blood to treat non-malignant disorders. For example, methods and materials for administering umbilical cord blood to a mammal (e.g., a human) via multiple (e.g., two or more) infusions to treat non-malignant diseases such as inherited disorders of metabolism, immunity, and/or hematopoiesis are provided.