A61K36/064

REDUCING OXYGEN LEVELS IN THE GASTROINTESTINAL TRACT

The present disclosure is directed towards a method of treating a disease or condition associated with gut inflammation. The present disclosure comprises administering, to a patient in need thereof, a composition comprising oxygen-scavenging membrane fragments or membrane vesicles. In some embodiments, membrane vesicles are derived from bacteria. In some embodiments, membrane vesicles are derived from the cytoplasmic membranes of Escherichia coli, Salmonella typhimurium, Gluconobacter oxydans, Pseudomonas aeruginosa, or Acetobacter.

METHOD FOR PREPARING ANTI-HEPATOMA DRUG SANJIE TABLET
20220362107 · 2022-11-17 ·

The present disclosure discloses a method for preparing an anti-hepatoma drug sanjie tablet, which includes a sanjie tablet containing components of Typhonii Rhizoma, exocarp of Juglans mandshurica, Dictamni Cortex and Bovis Calculus Artifactus. The preparation method includes the steps of: step 1. removing toxins from the components of Typhonii Rhizoma, exocarp of Juglans mandshurica and Dictamni Cortex in the sanjie tablet to obtain powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex; and step 2, uniformly mixing the powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex obtained in step 1 with Bovis Calculus Artifactus, granulating with a volatile medium, drying, tabletting, and conducting film-coating to obtain the sanjie tablet. Beneficial effects: the components in the composition of the sanjie tablet is decomposed and transformed by probiotics, and improving the medication safety of a patient in clinic.

METHOD FOR PREPARING ANTI-HEPATOMA DRUG SANJIE TABLET
20220362107 · 2022-11-17 ·

The present disclosure discloses a method for preparing an anti-hepatoma drug sanjie tablet, which includes a sanjie tablet containing components of Typhonii Rhizoma, exocarp of Juglans mandshurica, Dictamni Cortex and Bovis Calculus Artifactus. The preparation method includes the steps of: step 1. removing toxins from the components of Typhonii Rhizoma, exocarp of Juglans mandshurica and Dictamni Cortex in the sanjie tablet to obtain powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex; and step 2, uniformly mixing the powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex obtained in step 1 with Bovis Calculus Artifactus, granulating with a volatile medium, drying, tabletting, and conducting film-coating to obtain the sanjie tablet. Beneficial effects: the components in the composition of the sanjie tablet is decomposed and transformed by probiotics, and improving the medication safety of a patient in clinic.

METHOD FOR PREPARING ANTI-HEPATOMA DRUG SANJIE TABLET
20220362107 · 2022-11-17 ·

The present disclosure discloses a method for preparing an anti-hepatoma drug sanjie tablet, which includes a sanjie tablet containing components of Typhonii Rhizoma, exocarp of Juglans mandshurica, Dictamni Cortex and Bovis Calculus Artifactus. The preparation method includes the steps of: step 1. removing toxins from the components of Typhonii Rhizoma, exocarp of Juglans mandshurica and Dictamni Cortex in the sanjie tablet to obtain powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex; and step 2, uniformly mixing the powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex obtained in step 1 with Bovis Calculus Artifactus, granulating with a volatile medium, drying, tabletting, and conducting film-coating to obtain the sanjie tablet. Beneficial effects: the components in the composition of the sanjie tablet is decomposed and transformed by probiotics, and improving the medication safety of a patient in clinic.

DECONSTRUCTED SOIL
20220354881 · 2022-11-10 ·

The invention comprises a defined and safe soil substitute, herein referred to as “deconstructed soil”, that supports ecological balance in anaerobic microbial ecosystems, such as that inside the human gut, by shifting energy availability to favor growth of bacteria linked with gut health, and away from the most dominant species and species that are putatively harmful. The invention enables vulnerable bacterial groups to recover from a state of apparent extinction from the ecosystem in question. As it does not contain components that are prebiotic or probiotic, the deconstructed soil represents a new product concept for preventing and treating conditions associated with dysfunctional microbial ecosystems in the gastrointestinal tract of humans and animals, as well as other anaerobic microbial ecosystems.

DECONSTRUCTED SOIL
20220354881 · 2022-11-10 ·

The invention comprises a defined and safe soil substitute, herein referred to as “deconstructed soil”, that supports ecological balance in anaerobic microbial ecosystems, such as that inside the human gut, by shifting energy availability to favor growth of bacteria linked with gut health, and away from the most dominant species and species that are putatively harmful. The invention enables vulnerable bacterial groups to recover from a state of apparent extinction from the ecosystem in question. As it does not contain components that are prebiotic or probiotic, the deconstructed soil represents a new product concept for preventing and treating conditions associated with dysfunctional microbial ecosystems in the gastrointestinal tract of humans and animals, as well as other anaerobic microbial ecosystems.

MICROBIAL COMPOSITIONS AND METHODS FOR PRODUCING COMBINED PROBIOTIC ASSEMBLAGES

The present invention relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. These microbes are used to augment the effects of additional probiotic strains. The consumption of mixtures of these microbes at relevant doses will produce a beneficial effect in the host mediated in part by production of short chain fatty acids to enhance colonic butyrate production. Therapeutic methods of the invention involve the use of live microorganisms or metabolites derived from said microorganisms to establish a microbial composition in the mammalian host that will provide a health benefit to a mammal in need thereof.

MICROBIAL COMPOSITIONS AND METHODS FOR PRODUCING COMBINED PROBIOTIC ASSEMBLAGES

The present invention relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. These microbes are used to augment the effects of additional probiotic strains. The consumption of mixtures of these microbes at relevant doses will produce a beneficial effect in the host mediated in part by production of short chain fatty acids to enhance colonic butyrate production. Therapeutic methods of the invention involve the use of live microorganisms or metabolites derived from said microorganisms to establish a microbial composition in the mammalian host that will provide a health benefit to a mammal in need thereof.

Compositions Comprising Probiotic and Prebiotic Components and Mineral Salts, with Lactoferrin
20230045437 · 2023-02-09 ·

The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.

Compositions Comprising Probiotic and Prebiotic Components and Mineral Salts, with Lactoferrin
20230045437 · 2023-02-09 ·

The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.