The disclosure relates to the technical field of dietary nutritional supplements, in particular to a hirudin formula composition with anticoagulant and hypolipidemic effects and a preparation method thereof. Technical problem: the hirudin formula composition with anticoagulant and hypolipidemic effects and the preparation method thereof are intended to solve the technical problems that dietary nutritional supplements in the prior art cannot achieve anticoagulant and hypolipidemic effects. Technical solution: a hirudin formula composition with anticoagulant and hypolipidemic effects includes the following components by weight: 50 mg to 500 mg of hirudin polypeptide, 10 mg to 100 mg of red yeast rice, 10 mg to 100 mg of nattokinase, 10 mg to 100 mg of sulforaphane, 10 mg to 100 mg of agaricus blazei murill, 10 mg to 100 mg of quercetin, 10 mg to 300 mg of hirudin, and 50 mg to 300 mg of panax notoginseng extract.

The present disclosure relates to a complex polysaccharide for regulating Th1/Th2 immune balance and a preparation method and use thereof. The complex polysaccharide is prepared from medicinal and edible homologous plants and edible fungi as raw materials. The raw materials include Agaricus Blazei Murill, seaweed, glycyrrhiza, polygonatum and honeysuckle; and compared with current drugs for treating ovalbumin-induced immune stress, the complex polysaccharide can be taken for a long time without obvious toxic or side effects. Moreover, the complex polysaccharide obtains a molecular weight segment effective to immunomodulation through co-extraction, and has obvious synergistic benefits compared to the immunomodulatory effect of the single polysaccharide. The complex polysaccharide can regulate the Th1/Th2 immune balance, prevent and/or inhibit the ovalbumin-induced immune stress response, providing effective support for the wide application of the ovalbumin.

The present disclosure provides compositions able to prevent coronavirus infections. As demonstrated by the examples herein, compositions comprising an extract from Agaricus blazei, Grifola frondosa and Hericium erinaceus may interfere with the interaction between the Spike S1 protein and ACE2. Accordingly, such compositions may provide therapeutic or prophylactic alternatives to the known treatments.