Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and LDL and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation.

Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and LDL and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation.

A method for treating or suppressing inflammatory disease includes administering a composition to a subject in need thereof. The composition includes a composite extract of beet, red onion, and purple sweet potato as an active ingredient. The composition has no cytotoxicity, effectively inhibits NO-mediated inflammatory reactions, inhibits the production of IL-6 protein, and inhibits the expression of iNOS COX-2 genes, which are representative inflammation-related genes, thus having an excellent anti-inflammatory effect, and so it can be usefully used for the treatment and prevention of inflammatory diseases in cosmetics, food, and quasi-drug fields. In addition, the composition of the present invention is not only very safe to human body but also excellent in stability.

A method for treating or suppressing inflammatory disease includes administering a composition to a subject in need thereof. The composition includes a composite extract of beet, red onion, and purple sweet potato as an active ingredient. The composition has no cytotoxicity, effectively inhibits NO-mediated inflammatory reactions, inhibits the production of IL-6 protein, and inhibits the expression of iNOS COX-2 genes, which are representative inflammation-related genes, thus having an excellent anti-inflammatory effect, and so it can be usefully used for the treatment and prevention of inflammatory diseases in cosmetics, food, and quasi-drug fields. In addition, the composition of the present invention is not only very safe to human body but also excellent in stability.

A composition includes a cannabinoid agent in a range of 0.005% to 1%, a terpene agent in a range of 0.005% to 1%, and a co-fermented herbal complex in a range of 5% to 40%. The cannabinoid agent can include CBD, CBN, CBG, or a combination thereof. The composition can further include ashwagandha.

A composition includes a cannabinoid agent in a range of 0.005% to 1%, a terpene agent in a range of 0.005% to 1%, and a co-fermented herbal complex in a range of 5% to 40%. The cannabinoid agent can include CBD, CBN, CBG, or a combination thereof. The composition can further include ashwagandha.

A method for preparing a botanical extract includes extracting plant matter with ultrapure water, and separating the solid plant matter from the liquid fraction, concentrating the liquid fraction, and purifying the concentrated liquid fraction by tangential flow filtration.

This disclosure relates to an enzymatic method including the steps of adding water to a reactor vessel with gentle mixing and minimal heating, adding osmotic protectant solution, adding plant material to the reactor, adding cell wall degrading enzymes at 0.1% wt/wt based on plant weight, heating the reactor now filled with plant material, osmotic protectant solution and enzyme blend solution to 30° C.-35° C., adding the enzyme mixture to the reactor and starting the timer for up to 2 hours, adding bulk density enhancer, further mixing the product, and drying the finished product containing protoplasts. The protoplast containing product may be provided in a dietary supplement for human use having antioxidant and anti-inflammatory properties.

This disclosure relates to an enzymatic method including the steps of adding water to a reactor vessel with gentle mixing and minimal heating, adding osmotic protectant solution, adding plant material to the reactor, adding cell wall degrading enzymes at 0.1% wt/wt based on plant weight, heating the reactor now filled with plant material, osmotic protectant solution and enzyme blend solution to 30° C.-35° C., adding the enzyme mixture to the reactor and starting the timer for up to 2 hours, adding bulk density enhancer, further mixing the product, and drying the finished product containing protoplasts. The protoplast containing product may be provided in a dietary supplement for human use having antioxidant and anti-inflammatory properties.

A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.